TMEM51

TMEM51
Identifiers
AliasesTMEM51, C1orf72, transmembrane protein 51
External IDsMGI: 2384874; GeneCards: TMEM51
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

55092

214359

Ensembl

ENSG00000171729

ENSMUSG00000040616

UniProt

Q9NW97
Q9BSA0

Q99LG1

RefSeq (mRNA)

NM_001136216
NM_001136217
NM_001136218
NM_018022
NM_001319665

NM_145402

RefSeq (protein)

NP_663377

Location (UCSC)Chr 1: 15.15 – 15.22 MbChr 4: 141.76 – 141.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Pairwise Alignment of Human (Homo sapiens) TMEM51 and Zebrafish (Danio rerio) TMEM51 Amino Acid Sequences

Transmembrane protein 51 is a protein in humans that is encoded by the TMEM51 gene.[5] It is located on the first chromosome (1p36.21) and has 6 isoforms in humans.[6] It has orthologs in mammals, birds, reptiles, amphibians, and fish.[6]

It is predicted to be a transmembrane protein due to the transmembrane regions within its coding sequence.[7]

TMEM51-AS1 (a long non-coding RNA from the TMEM51 locus) acts as a tumor suppressor when overexpressed, inhibiting cancer cell progression.[8] Mutations or polymorphisms of the TMEM51 are associated susceptibility to Reynaud's syndrome.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171729 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040616 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Transmembrane protein 51". Retrieved 2012-10-29.
  6. ^ a b "AceView: Gene:TMEM51, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2025-09-29.
  7. ^ "Homo sapiens transmembrane protein 51 (TMEM51), transcript variant 1, mRNA". NCBI. 2025-04-27.
  8. ^ Wu D, Xia Q, Su X, Mao Y, Mao J, Ding Q, et al. (May 2025). "Long non-coding RNA TMEM51-AS1 inhibits colorectal cancer progression". Discover Oncology. 16 (1) 878. doi:10.1007/s12672-025-02676-z. PMC 12102048. PMID 40407985.
  9. ^ Tervi A, Ramste M, Abner E, Cheng P, Lane JM, Maher M, et al. (September 2024). "Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity". Cell Genomics. 4 (9) 100630. doi:10.1016/j.xgen.2024.100630. PMC 11480858. PMID 39142284.
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