TRIM68

TRIM68
Identifiers
AliasesTRIM68, GC109, RNF137, SS-56, SS56, tripartite motif containing 68
External IDsOMIM: 613184; MGI: 2142077; GeneCards: TRIM68
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.3.2.27↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

55128

101700

Ensembl

ENSG00000167333

ENSMUSG00000073968

UniProt

Q6AZZ1

Q8K243

RefSeq (mRNA)

NM_018073
NM_001304496

NM_198012
NM_001307998

RefSeq (protein)

NP_001291425
NP_060543

n/a

Location (UCSC)Chr 11: 4.6 – 4.61 MbChr 7: 102.33 – 102.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.[5][6]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.[6]

Interactions

TRIM68 has been shown to interact with Androgen receptor.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167333 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073968 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chang GT, Steenbeek M, Schippers E, Blok LJ, van Weerden WM, van Alewijk DC, et al. (November 2001). "A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells". European Journal of Cancer. 37 (16): 2129–34. doi:10.1016/S0959-8049(01)00259-3. PMID 11597395.
  6. ^ a b "Entrez Gene: TRIM68 tripartite motif-containing 68".
  7. ^ Miyajima N, Maruyama S, Bohgaki M, Kano S, Shigemura M, Shinohara N, et al. (May 2008). "TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells". Cancer Research. 68 (9): 3486–94. doi:10.1158/0008-5472.CAN-07-6059. PMID 18451177.

Further reading


Stub icon

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.