TRIP6

TRIP6
Identifiers
AliasesTRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6
External IDsOMIM: 602933; MGI: 1343458; GeneCards: TRIP6
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

7205

22051

Ensembl

ENSG00000087077

ENSMUSG00000023348

UniProt

Q15654

Q9Z1Y4

RefSeq (mRNA)

NM_003302

NM_011639

RefSeq (protein)

NP_003293

NP_035769

Location (UCSC)Chr 7: 100.87 – 100.87 MbChr 5: 137.31 – 137.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.[5][6][7]

Function

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[7]

Interactions

TRIP6 has been shown to interact with LPAR2,[8] BCAR1[8][9] and HOXA9.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087077 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023348 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yi J, Beckerle MC (Apr 1998). "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis". Genomics. 49 (2): 314–6. doi:10.1006/geno.1998.5248. PMID 9598321.
  6. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
  7. ^ a b "Entrez Gene: TRIP6 thyroid hormone receptor interactor 6".
  8. ^ a b Xu J, Lai YJ, Lin WC, Lin FT (Mar 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". The Journal of Biological Chemistry. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMC 3904432. PMID 14688263.
  9. ^ Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
  10. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q15654 (Thyroid receptor-interacting protein 6) at the PDBe-KB.


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