TUBGCP4

TUBGCP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RIP
Identifiers
Aliases	TUBGCP4, 76P, GCP-4, GCP4, Grip76, MCCRP3, tubulin gamma complex associated protein 4
External IDs	OMIM: 609610; MGI: 1196293; HomoloGene: 8690; GeneCards: TUBGCP4; OMA:TUBGCP4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	43,409,771 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	121,029,251 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; buccal mucosa cell; ; ganglionic eminence; ; ventricular zone; ; gonad; ; testicle; ; tibialis anterior muscle; ; epithelium of colon; ; cerebellar hemisphere;
	Top expressed in
	ascending aorta; ; spermatocyte; ; tail of embryo; ; genital tubercle; ; aortic valve; ; supraoptic nucleus; ; neural layer of retina; ; internal carotid artery; ; thymus; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of cytoskeleton; microtubule minus-end binding; protein binding; gamma-tubulin binding;
Cellular component	cytoplasm; microtubule organizing center; gamma-tubulin complex; cytosol; spindle pole body; spindle pole; recycling endosome; equatorial microtubule organizing center; membrane; microtubule; microtubule cytoskeleton; cytoskeleton; centrosome;
Biological process	microtubule nucleation by interphase microtubule organizing center; microtubule cytoskeleton organization; mitotic spindle assembly; centrosome duplication; cytoplasmic microtubule organization; microtubule nucleation; meiosis; mitotic cell cycle; spindle assembly; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	27229
	51885
	ENSG00000137822
	ENSMUSG00000027263
	Q9UGJ1
	Q9D4F8
	NM_001286414; NM_014444
	NM_001290824; NM_153387
	NP_001273343; NP_055259
	NP_001277753; NP_700436
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene.^[5] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137822 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027263 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tubulin, gamma complex associated protein 4".

Hsu HL, Yeh NH (February 1996). "Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis". Journal of Cell Science. 109 ( Pt 2) (2): 277–88. doi:10.1242/jcs.109.2.277. PMID 8838651.
Haren L, Merdes A (May 2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules". Journal of Cell Science. 115 (Pt 9): 1815–24. doi:10.1242/jcs.115.9.1815. PMID 11956313.
Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (November 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Molecular Biology of the Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
Fava F, Raynaud-Messina B, Leung-Tack J, Mazzolini L, Li M, Guillemot JC, Cachot D, Tollon Y, Ferrara P, Wright M (November 1999). "Human 76p: A new member of the gamma-tubulin-associated protein family". The Journal of Cell Biology. 147 (4): 857–68. doi:10.1083/jcb.147.4.857. PMC 2156165. PMID 10562286.
Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.