Epithelial cell type
A Toker cell is an epithelial cell with clear cytoplasm in the nipple of some women.[1] Toker cells are believed to develop from sebaceous glands.[1] They are cytokeratin 7 (CK7) positive, in contrast to squamous epithelium.[1] Rarely, they can be numerous and atypical, and difficult to distinguish from malignant cells of Paget's disease of the breast.[2] In such cases, immunohistochemistry using CD138 and p53 can be used for distinction, both being negative in Toker cells and positive in Paget's disease.[2]
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