Share to:

Tubulin beta-4B chain

TUBB4B

Identifiers

TUBB4B, Beta2, TUBB2, TUBB2C, tubulin beta 4B class IVb, LCAEOD

External IDs

OMIM: 602660; MGI: 1915472; HomoloGene: 68504; GeneCards: TUBB4B; OMA:TUBB4B - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q34.3	Start	137,241,287 bp^[1]
Band	9q34.3	End	137,243,707 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A3	Start	25,112,172 bp^[2]
Band	2\|2 A3	End	25,114,714 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right testis

left testis

bronchial epithelial cell

right uterine tube

spinal ganglia

olfactory zone of nasal mucosa

pars compacta

mucosa of ileum

orbitofrontal cortex

Brodmann area 46

Top expressed in

spermatid

testicle

spermatocyte

primary oocyte

secondary oocyte

Hypothalamus

esophagus

bone marrow

lens

epiblast

More reference expression data


More reference expression data

Gene ontology
Molecular function	nucleotide binding unfolded protein binding GTP binding structural constituent of cytoskeleton GTPase activity double-stranded RNA binding MHC class I protein binding
Cellular component	cytoplasm extracellular vesicle cytosol myelin sheath microtubule cytoskeleton extracellular exosome nucleus extracellular matrix extracellular region microtubule cytoskeleton azurophil granule lumen
Biological process	G2/M transition of mitotic cell cycle microtubule-based process natural killer cell mediated cytotoxicity cytoskeleton organization neutrophil degranulation ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle microtubule cytoskeleton organization mitotic cell cycle
Sources:Amigo / QuickGO

Species

Human

Mouse


10383


227613


ENSG00000188229


ENSMUSG00000036752


P68371


P68372

RefSeq (mRNA)


NM_006088


NM_146116

RefSeq (protein)


NP_006079


NP_666228

Location (UCSC)

Chr 9: 137.24 – 137.24 Mb

Chr 2: 25.11 – 25.11 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.^[5]^[6] It is thought that this protein could determine which hand is dominant in humans due to variations of the TUBB4B gene, which cause the protein to form microtubules that form cilia which direct fluids asymmetrically during development.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188229 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036752 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lewis SA, Gilmartin ME, Hall JL, Cowan NJ (Jul 1985). "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype". J Mol Biol. 182 (1): 11–20. doi:10.1016/0022-2836(85)90023-3. PMID 3999141.
^ "Entrez Gene: TUBB2C tubulin, beta 2C".
^ Kulkarni, Sumeet (2024-04-02). "Right- or left-handed? Protein in embryo cells might help decide". Nature. doi:10.1038/d41586-024-00977-x.

Further reading

Burgoyne RD, Cambray-Deakin MA, Lewis SA, et al. (1989). "Differential distribution of beta-tubulin isotypes in cerebellum". EMBO J. 7 (8): 2311–9. doi:10.1002/j.1460-2075.1988.tb03074.x. PMC 457095. PMID 2461292.
Wang D, Villasante A, Lewis SA, Cowan NJ (1987). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype". J. Cell Biol. 103 (5): 1903–10. doi:10.1083/jcb.103.5.1903. PMC 2114403. PMID 3782288.
Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
Szalay J, Bruno P, Bhati R, et al. (2001). "Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells". J. Histochem. Cytochem. 49 (1): 49–66. doi:10.1177/002215540104900106. PMID 11118478. S2CID 41666892.
Tarazona R, López-Lluch G, Galiani MD, et al. (2001). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity". J. Immunol. 165 (12): 6776–82. doi:10.4049/jimmunol.165.12.6776. PMID 11120798.
Walss-Bass C, Xu K, David S, et al. (2003). "Occurrence of nuclear beta(II)-tubulin in cultured cells". Cell Tissue Res. 308 (2): 215–23. doi:10.1007/s00441-002-0539-6. PMID 12037579. S2CID 25518226.
Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
Dozier JH, Hiser L, Davis JA, et al. (2003). "β class II tubulin predominates in normal and tumor breast tissues". Breast Cancer Res. 5 (5): R157–69. doi:10.1186/bcr631. PMC 314434. PMID 12927047.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology. 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.

External links

TUBB4B human gene location in the UCSC Genome Browser.
TUBB4B human gene details in the UCSC Genome Browser.

PDB gallery

1ffx: TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
1ia0: KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM
1jff: Refined structure of alpha-beta tubulin from zinc-induced sheets stabilized with taxol
1sa0: TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX
1sa1: Tubulin-podophyllotoxin: stathmin-like domain complex
1tub: TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION
1tvk: The binding mode of epothilone A on a,b-tubulin by electron crystallography
1z2b: Tubulin-colchicine-vinblastine: stathmin-like domain complex
2hxf: KIF1A head-microtubule complex structure in amppnp-form
2hxh: KIF1A head-microtubule complex structure in adp-form

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

Index: pl ar de en es fr it arz nl ja pt ceb sv uk vi war zh ru af ast az bg zh-min-nan bn be ca cs cy da et el eo eu fa gl ko hi hr id he ka la lv lt hu mk ms min no nn ce uz kk ro simple sk sl sr sh fi ta tt th tg azb tr ur zh-yue hy my ace als am an hyw ban bjn map-bms ba be-tarask bcl bpy bar bs br cv nv eml hif fo fy ga gd gu hak ha hsb io ig ilo ia ie os is jv kn ht ku ckb ky mrj lb lij li lmo mai mg ml zh-classical mr xmf mzn cdo mn nap new ne frr oc mhr or as pa pnb ps pms nds crh qu sa sah sco sq scn si sd szl su sw tl shn te bug vec vo wa wuu yi yo diq bat-smg zu lad kbd ang smn ab roa-rup frp arc gn av ay bh bi bo bxr cbk-zam co za dag ary se pdc dv dsb myv ext fur gv gag inh ki glk gan guw xal haw rw kbp pam csb kw km kv koi kg gom ks gcr lo lbe ltg lez nia ln jbo lg mt mi tw mwl mdf mnw nqo fj nah na nds-nl nrm nov om pi pag pap pfl pcd krc kaa ksh rm rue sm sat sc trv stq nso sn cu so srn kab roa-tara tet tpi to chr tum tk tyv udm ug vep fiu-vro vls wo xh zea ty ak bm ch ny ee ff got iu ik kl mad cr pih ami pwn pnt dz rmy rn sg st tn ss ti din chy ts kcg ve

Prefix: a b c d e f g h i j k l m n o p q r s t u v w x y z 0 1 2 3 4 5 6 7 8 9

Portal di Ensiklopedia Dunia

Kembali kehalaman sebelumnya