After going undrafted in the 2015 NFL draft, Burwell signed with the San Diego Chargers on May 3, 2015.[1] On September 10, he was waived, but signed to the practice squad two days later.[2] He was promoted to the active roster on September 29.[3]
On November 5, 2016, Burwell was released by the Chargers.[4] Three days later, the Chargers signed Burwell to their practice squad.[5] He was promoted to the active roster on November 14.
On September 2, 2017, Burwell was waived by the Chargers.[6]
Indianapolis Colts
On September 11, 2017, Burwell was signed to Indianapolis Colts' practice squad.[7] He was promoted to the active roster on November 2, 2017.[8]
On September 1, 2018, Burwell was waived/injured by the Colts and was placed on injured reserve.[9] He was released on September 5, 2018.
Philadelphia Eagles
On January 9, 2019, Burwell signed a reserve/future contract with the Philadelphia Eagles.[10] On July 15, 2019, Burwell announced his retirement from the NFL.[11]