UFSP2
| UFSP2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | UFSP2, C4orf20, BHD, UFM1-specific peptidase 2, UFM1 specific peptidase 2, SEMDDR | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611482; MGI: 1913679; GeneCards: UFSP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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UFM1 specific peptidase 2 is a protein that in humans is encoded by the UFSP2 gene.[5]
Function
This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109775 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031634 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: UFM1 specific peptidase 2". Retrieved 2020-04-15.
 | This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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