At the Università Cattolica del Sacro Cuore itself, he taught from 1980 to 1986, then moved on to an academic career at the University of Venice (1987) and then at the Loyola University of Chicago, the Sorbonne University in Paris and the Bocconi University in Milan. However, due to his numerous commitments, both national and international, he can no longer lecture full-time, but he holds a visiting professor role.[2]
Between the 1970s and the 1980s, he has undertaken the "Anabasis" expeditions for the reconstruction of the itinerary of the Ten Thousand's retreat. This expedition covered a total of 18,000 km, with 2,000 photographs being taken. He undertook and led numerous other expeditions, such as: Lavinium, Forum Gallorum and Forte Urbano in Italy, Túcume (Peru), Har Karkom and other overseas locations.[3]
He has published many academic essays and articles and he has written several best-selling novels (amounting to a total of about 8 million copies sold worldwide). He also writes on many newspapers and magazines as a scientific journalist both in Italy (e.g., "Il Messaggero", "Panorama", "Archeo", "Focus") and in Spain (Spanish edition of "Focus" and "El Mundo").[4]
His novel The Last Legion was the basis for the movie of the same title, released in 2007 and starring Colin Firth, Ben Kingsley and others; his Alexander Trilogy has been bought by Universal Pictures for yet another cinematic rendition of the story of Alexander the Great.[1] He has also written the screenplays for Marco d'Aviano and Gilgamesh and he has adapted Le Memorie di Adriano for cinema screening. Furthermore, he has hosted the television series Stargate – linea di confine for three seasons already on the Italian TV channel LA7 and he will also host Impero (Empire) on the very same channel.
On 11 February 2021, Manfredi and fellow writer Antonella Prenner were found unconscious at his home in Rome, after suffering a domestic incident caused by an accidental gas leak. They were hospitalized in Grosseto; their conditions were described as critical.[5] They were later released.
