Villa Sant'Antonio (Sant'Antoni in Sardinian language) is a comune (municipality) in the Province of Oristano in the Italian region Sardinia, located about 70 kilometres (43 mi) north of Cagliari and about 25 kilometres (16 mi) east of Oristano.
Villa Sant'Antonio borders the following municipalities: Albagiara, Assolo, Asuni, Mogorella, Ruinas, Senis.
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