YAF2

YAF2
Identifiers
AliasesYAF2, YY1 associated factor 2
External IDsOMIM: 607534; MGI: 1914307; GeneCards: YAF2
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

10138

67057

Ensembl

ENSG00000015153

ENSMUSG00000022634

UniProt

Q8IY57

Q99LW6

RefSeq (mRNA)

NM_024189

RefSeq (protein)

NP_001177906
NP_001177908
NP_001177909
NP_001307009
NP_005739

NP_077151

Location (UCSC)Chr 12: 42.16 – 42.24 MbChr 15: 93.18 – 93.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.[5][6]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000015153 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022634 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Mar 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
  6. ^ a b "Entrez Gene: YAF2 YY1 associated factor 2".

Further reading


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