Class of enzymes
The enzyme α-N -acetylglucosaminidase (EC 3.2.1.50 , α-acetylglucosaminidase , N-acetyl-α-D-glucosaminidase , N-acetyl-α-glucosaminidase , α-D-2-acetamido-2-deoxyglucosidase ) is a protein associated with Sanfilippo syndrome , with systematic name α-N -acetyl-D -glucosaminide N -acetylglucosaminohydrolase.[ 2] [ 3] [ 4] [ 5] It catalyses the hydrolysis of terminal non-reducing N -acetyl-D -glucosamine residues in N -acetyl-α-D -glucosaminides, and also UDP-N -acetylglucosamine .
References
^ Birrane, Gabriel; Dassier, Anne-Laure; Romashko, Alla; Lundberg, Dianna; Holmes, Kevin; Cottle, Thomas; Norton, Angela W.; Zhang, Bohong; Concino, Michael F.; Meiyappan, Muthuraman (2019). "Structural characterization of the α-N -acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B" . Journal of Structural Biology . 205 (3): 65–71. doi :10.1016/j.jsb.2019.02.005 . PMID 30802506 . S2CID 73482664 .
^ von Figura K (November 1977). "Human α-N -acetylglucosaminidase. 1. Purification and properties" . European Journal of Biochemistry . 80 (2): 523–533. doi :10.1111/j.1432-1033.1977.tb11908.x . PMID 411658 .
^ von Figura K (November 1977). "Human α-N -acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms" . European Journal of Biochemistry . 80 (2): 535–542. doi :10.1111/j.1432-1033.1977.tb11909.x . PMID 923593 .
^ Weissmann B, Rowin G, Marshall J, Friederici D (January 1967). "Mammalian α-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization". Biochemistry . 6 (1): 207–214. doi :10.1021/bi00853a033 . PMID 4291567 .
^ Werries E, Wollek E, Gottschalk A, Buddecke E (October 1969). "Separation of N -acetyl-α-glucosaminidase and N -acetyl-α-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N -acetyl-α-galactosaminidase" . European Journal of Biochemistry . 10 (3): 445–449. doi :10.1111/j.1432-1033.1969.tb00709.x . PMID 5348072 .
External links
Activity Regulation Classification Kinetics Types