DOCK2

DOCK2
Structure de la protéine DOCK2. Basé sur l'identifiant PDB 2RQR.
Structures disponibles
PDBRecherche d'orthologue : PDBe RCSB
Identifiants
AliasDOCK2, Dedicator of cytokinesis 2
IDs externesOMIM: 603122 MGI: 2149010 HomoloGene: 37984 GeneCards: DOCK2
Wikidata
Voir/Editer HumainVoir/Editer Souris

Le DOCK2 (pour « Dedicator of cytokinesis 2 ») est une protéine, membre de la famille des DOCKs, dont le gène, DOCK2, est situé sur le chromosome 5 humain.

Rôles

Elle permet la migration des lymphocytes[5] et des cellules dendritiques de type plasmacytoïde[6], intervenant dans la sécrétion d'interférons de type 1[7]. Elle active la protéine Rac, et par ce biais, les lymphocytes NK[8].

En médecine

La mutation du gène entraîne une immunodéficience congénitale combinée (intéressant les lymphocytes B et T) et sévère[9].

Notes et références

  1. ↑ a b et c GRCh38: Ensembl release 89: ENSG00000134516 - Ensembl, May 2017
  2. ↑ a b et c GRCm38: Ensembl release 89: ENSMUSG00000020143 - Ensembl, May 2017
  3. ↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
  4. ↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
  5. ↑ Fukui Y, Hashimoto O, Sanui T et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration, Nature, 2001;412:826-831
  6. ↑ Gotoh K, Tanaka Y, Nishikimi A et al. Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells, Blood, 2008;111:2973-2976
  7. ↑ Gotoh K, Tanaka Y, Nishikimi A et al. Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation, J Exp Med, 2010;207:721-730
  8. ↑ Sakai Y, Tanaka Y, Yanagihara T et al. The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation, Blood, 2013;122:386-393
  9. ↑ Dobbs K, Conde CD, Zhang SY et al. Inherited DOCK2 deficiency in patients with early-onset invasive infections, N Engl J Med, 2015;372:2409-2422
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