SOCS
Les SOCS (acronyme de suppressor of cytokine signaling) sont une famille de protéines, codées par des gènes du même nom, qui chez les mammifères ont en commun de supprimer les signaux cytokiniques.
Ils contribuent donc à réduire l'inflammation ou l'apoptose induite par le système immunitaire pour combattre les infections.
Leur absence — ou une mutation non- fonctionnelle — peut être létale[1].
Notes et références
- ↑ (en) Starr R, Metcalf D, Elefanty AG. et al., « Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1 », Proc Natl Acad Sci U S A., no 95, , p. 14395–9. (lire en ligne)
Voir aussi
Bibliographie
- (en) Ren, S., Chen, X., Huang, R., Zhou, G. G., & Yuan, Z, « SOCS4 expressed by recombinant HSV protects against cytokine storm in a mouse model », Oncology reports, vol. 41, no 3, , p. 1509-20. (lire en ligne)
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