TAFI

Le TAFI (de l'anglais thrombin-activatable fibrinolysis inhibitor) est une enzyme inhibitrice de la liaison plasminogène-fibrine dans la fibrinolyse[1], inhibant cette dernière. Son gène est le CPB2 situé sur le chromosome 13 humain.

Il est synthétisé essentiellement dans le foie[2].

Il retire la lysine ou l'arginine au bout de l'extrémité C-terminale de plusieurs protéines, dont la plasmine, la bradykinine, l'ostéopontine, permettant de moduler l'inflammation[3].

Le polymorphisme génétique du gène augmente le risque de maladie thromboembolique[4].

Notes et références

  1. ↑ Laszlo Bajzar, Reg Manuel, Michael E. Nesheim, « Purification and Characterization of TAFI, a Thrombin-Activable Fibrinolysis Inhibitor », Journal of Biological Chemistry, vol. 270, no 24,‎ , p. 14477-14484 (ISSN 0021-9258 et 1083-351X, PMID 7782309, DOI 10.1074/jbc.270.24.14477, lire en ligne, consulté le )
  2. ↑ Singh S, Kumar P, Padwad YS, Jaffer FA, Reed GL, Targeting fibrinolytic inhibition for venous thromboembolism treatment: Overview of an emerging therapeutic approach, Circulation, 2024;150!884-898
  3. ↑ Plug T, Meijers JC, Structure-function relationships in thrombin-activatable fibrinolysis inhibitor, J Thromb Haemost, 2016;14:633–644
  4. ↑ Qian K, Xu J, Wan H, Fu F, Lu J, Lin Z, Liu Z, Liu H, Impact of genetic polymorphisms in thrombin activatable fibrinolysis inhibitor (TAFI) on venous thrombosis disease: a meta-analysis, Gene, 2015;569:173–181
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Facteurs de la coagulation
Inhibiteurs
Fibrinolyse
Tests
Traitements

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