CHES

CHES
이름
우선명 (PIN)
2-(사이클로헥실아미노)에탄-1-설폰산
별칭
N-사이클로헥실-2-아미노에탄설폰산; N-사이클로헥실타우린
식별자
3D 모델 (JSmol)
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.002.832
MeSH 2-(N-cyclohexylamino)ethanesulfonic+acid
UNII
  • InChI=1S/C8H17NO3S/c10-13(11,12)7-6-9-8-4-2-1-3-5-8/h8-9H,1-7H2,(H,10,11,12) 예예
    Key: MKWKNSIESPFAQN-UHFFFAOYSA-N 예예
  • InChI=1/C8H17NO3S/c10-13(11,12)7-6-9-8-4-2-1-3-5-8/h8-9H,1-7H2,(H,10,11,12)
    Key: MKWKNSIESPFAQN-UHFFFAOYAH
  • O=S(=O)(O)CCNC1CCCCC1
성질
C8H17NO3S
몰 질량 207.29 g·mol−1
산성도 (pKa) 9.3
달리 명시된 경우를 제외하면, 표준상태(25 °C [77 °F], 100 kPa)에서 물질의 정보가 제공됨.
예예 확인 (관련 정보 예예아니오아니오 ?)

CHES(N-사이클로헥실-2-아미노에탄설폰산, N-cyclohexyl-2-aminoethanesulfonic acid)은 완충제이다. CHES 완충액은 pH 8.6–10 범위에서 유용하다.[1]

일반적으로 흰색 결정성 분말로 나타난다.

불순물의 영향

CHES (및 설포닐에틸 완충액인 MES, BES, PIPES)의 상업적 제조에는 RNA의 폴리음이온 모방체인 오리고(비닐설폰산) (OVS) 오염물질이 포함될 수 있으며, 이는 RNA 결합 단백질 및 효소의 강력한 (pM) 억제제가 될 수 있다.[2]

각주

  1. ↑ “Good's buffers (biological buffers)” (PDF). 
  2. ↑ Smith, Bryan D.; Soellner, Matthew B.; Raines, Ronald T. (2003). 《Potent Inhibition of Ribonuclease A by Oligo(vinylsulfonic Acid)》. 《Journal of Biological Chemistry》 278 (Elsevier BV). 20934–20938쪽. doi:10.1074/jbc.m301852200. ISSN 0021-9258. 

외부 링크

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