DEC2

BHLHE41
식별자
다른 이름BHLHE41, DEC2, SHARP1, BHLHe41, HDEC2, SHARP-1, BHLHB3, Basic Helix-Loop-Helix Family Member E41, Basic Helix-Loop-Helix Family, Member E41, Class E Basic Helix-Loop-Helix Protein 41, Class B Basic Helix-Loop-Helix Protein 3, Basic Helix-Loop-Helix Domain Containing, Class B, 3, Differentially Expressed In Chondrocytes 2, Differentially Expressed In Chondrocytes Protein 2, Enhancer-Of-Split And Hairy-Related Protein 1, FNSS1
외부 IDOMIM: 606200 MGI: 1930704 HomoloGene: 137401 GeneCards: BHLHE41
RNA 발현 패턴
Bgee
인간쥐(동원체)
최상위 발현
  • 오른자궁관

  • 미주신경 아래신경절

  • 아킬레스건

  • 시신경

  • subthalamic nucleus

  • 척수

  • C1 segment

  • 뇌량

  • pars reticulata

  • external globus pallidus
최상위 발현
  • neural layer of retina

  • muscle of thigh

  • 수정란

  • superior frontal gyrus

  • primary visual cortex

  • cerebellar cortex

  • dentate gyrus of hippocampal formation granule cell

  • 골격근 조직

  • 심실중격

  • 입술
추가 참조 발현 데이터
BioGPS
추가 참조 발현 데이터
위키데이터
인간 보기/편집쥐 보기/편집

BHLHE41(Basic helix-loop-helix family, member e41)은 인간과 생쥐의 다양한 조직에서 bHLH(basic helix-loop-helix) 전사인자(transcription factor,TF) 억제 단백질을 암호화하는 유전자이다.[5][6][7][8] DEC2, hDEC2 및 SHARP1이라고도하며 이전에는 BHLHB3(basic helix-loop-helix domain containing, class B, 3)으로 알려져있었다.[9] BHLHE41은 수면량에 영향을 미치는 일주기 분자 메커니즘에서의 역할뿐만 아니라 면역 기능에서의 역할 및 체액 면역과 관련된 보조 T세포(Helper T cell)의 T보조2형 세포(T helper type 2 cell ) 계통의 성숙으로 알려져있다.[10][11]

생체시계 유전자

이러한 생체시계와 관련된 유전자로 밝혀진 것으로는 Period, NCX2, CLOCK, TP53 등이 있다.

같이 보기

참고

  1. ↑ 가 나 다 GRCh38: Ensembl release 89: ENSG00000123095 - 앙상블, May 2017
  2. ↑ 가 나 다 GRCm38: Ensembl release 89: ENSMUSG00000030256 - 앙상블, May 2017
  3. ↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》. 
  4. ↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》. 
  5. ↑ “BHLHE41 basic helix-loop-helix family, member e41 [ Homo sapiens (human) ]”. National Center for Biotechnology Information. 
  6. ↑ “Bhlhe41 basic helix-loop-helix family, member e41 [ Mus musculus (house mouse) ]”. NCBI. 
  7. ↑ Stevens JD, Roalson EH, Skinner MK (November 2008). “Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation”. 《Differentiation; Research in Biological Diversity》 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763. 
  8. ↑ “Entrez Gene: BHLHB3 basic helix-loop-helix domain containing, class B, 3”. 
  9. ↑ “Basic Helix-Loop-Helix Family, Member E41”. Weizmann Institute of Science. 2014년 5월 28일에 원본 문서에서 보존된 문서. 2014년 5월 27일에 확인함. 
  10. ↑ Kurien PA, Chong SY, Ptáček LJ, Fu YH (October 2013). “Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function”. 《Current Opinion in Neurobiology》 23 (5): 873–9. doi:10.1016/j.conb.2013.04.014. PMC 3766463. PMID 23702243. 
  11. ↑ Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C (December 2009). “Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment” (영어). 《Nature Immunology》 10 (12): 1260–6. doi:10.1038/ni.1821. PMC 2784129. PMID 19881507. 

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