LYST (англ. Lysosomal trafficking regulator) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 3 801 амінокислот, а молекулярна маса — 429 139[5].
Послідовність амінокислот
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MSTDSNSLAR | | EFLTDVNRLC | | NAVVQRVEAR | | EEEEEETHMA | | TLGQYLVHGR |
| GFLLLTKLNS | | IIDQALTCRE | | ELLTLLLSLL | | PLVWKIPVQE | | EKATDFNLPL |
| SADIILTKEK | | NSSSQRSTQE | | KLHLEGSALS | | SQVSAKVNVF | | RKSRRQRKIT |
| HRYSVRDARK | | TQLSTSDSEA | | NSDEKGIAMN | | KHRRPHLLHH | | FLTSFPKQDH |
| PKAKLDRLAT | | KEQTPPDAMA | | LENSREIIPR | | QGSNTDILSE | | PAALSVISNM |
| NNSPFDLCHV | | LLSLLEKVCK | | FDVTLNHNSP | | LAASVVPTLT | | EFLAGFGDCC |
| SLSDNLESRV | | VSAGWTEEPV | | ALIQRMLFRT | | VLHLLSVDVS | | TAEMMPENLR |
| KNLTELLRAA | | LKIRICLEKQ | | PDPFAPRQKK | | TLQEVQEDFV | | FSKYRHRALL |
| LPELLEGVLQ | | ILICCLQSAA | | SNPFYFSQAM | | DLVQEFIQHH | | GFNLFETAVL |
| QMEWLVLRDG | | VPPEASEHLK | | ALINSVMKIM | | STVKKVKSEQ | | LHHSMCTRKR |
| HRRCEYSHFM | | HHHRDLSGLL | | VSAFKNQVSK | | NPFEETADGD | | VYYPERCCCI |
| AVCAHQCLRL | | LQQASLSSTC | | VQILSGVHNI | | GICCCMDPKS | | VIIPLLHAFK |
| LPALKNFQQH | | ILNILNKLIL | | DQLGGAEISP | | KIKKAACNIC | | TVDSDQLAQL |
| EETLQGNLCD | | AELSSSLSSP | | SYRFQGILPS | | SGSEDLLWKW | | DALKAYQNFV |
| FEEDRLHSIQ | | IANHICNLIQ | | KGNIVVQWKL | | YNYIFNPVLQ | | RGVELAHHCQ |
| HLSVTSAQSH | | VCSHHNQCLP | | QDVLQIYVKT | | LPILLKSRVI | | RDLFLSCNGV |
| SQIIELNCLN | | GIRSHSLKAF | | ETLIISLGEQ | | QKDASVPDID | | GIDIEQKELS |
| SVHVGTSFHH | | QQAYSDSPQS | | LSKFYAGLKE | | AYPKRRKTVN | | QDVHINTINL |
| FLCVAFLCVS | | KEAESDRESA | | NDSEDTSGYD | | STASEPLSHM | | LPCISLESLV |
| LPSPEHMHQA | | ADIWSMCRWI | | YMLSSVFQKQ | | FYRLGGFRVC | | HKLIFMIIQK |
| LFRSHKEEQG | | KKEGDTSVNE | | NQDLNRISQP | | KRTMKEDLLS | | LAIKSDPIPS |
| ELGSLKKSAD | | SLGKLELQHI | | SSINVEEVSA | | TEAAPEEAKL | | FTSQESETSL |
| QSIRLLEALL | | AICLHGARTS | | QQKMELELPN | | QNLSVESILF | | EMRDHLSQSK |
| VIETQLAKPL | | FDALLRVALG | | NYSADFEHND | | AMTEKSHQSA | | EELSSQPGDF |
| SEEAEDSQCC | | SFKLLVEEEG | | YEADSESNPE | | DGETQDDGVD | | LKSETEGFSA |
| SSSPNDLLEN | | LTQGEIIYPE | | ICMLELNLLS | | ASKAKLDVLA | | HVFESFLKII |
| RQKEKNVFLL | | MQQGTVKNLL | | GGFLSILTQD | | DSDFQACQRV | | LVDLLVSLMS |
| SRTCSEELTL | | LLRIFLEKSP | | CTKILLLGIL | | KIIESDTTMS | | PSQYLTFPLL |
| HAPNLSNGVS | | SQKYPGILNS | | KAMGLLRRAR | | VSRSKKEADR | | ESFPHRLLSS |
| WHIAPVHLPL | | LGQNCWPHLS | | EGFSVSLWFN | | VECIHEAEST | | TEKGKKIKKR |
| NKSLILPDSS | | FDGTESDRPE | | GAEYINPGER | | LIEEGCIHII | | SLGSKALMIQ |
| VWADPHNATL | | IFRVCMDSND | | DMKAVLLAQV | | ESQENIFLPS | | KWQHLVLTYL |
| QQPQGKRRIH | | GKISIWVSGQ | | RKPDVTLDFM | | LPRKTSLSSD | | SNKTFCMIGH |
| CLSSQEEFLQ | | LAGKWDLGNL | | LLFNGAKVGS | | QEAFYLYACG | | PNHTSVMPCK |
| YGKPVNDYSK | | YINKEILRCE | | QIRELFMTKK | | DVDIGLLIES | | LSVVYTTYCP |
| AQYTIYEPVI | | RLKGQMKTQL | | SQRPFSSKEV | | QSILLEPHHL | | KNLQPTEYKT |
| IQGILHEIGG | | TGIFVFLFAR | | VVELSSCEET | | QALALRVILS | | LIKYNQQRVH |
| ELENCNGLSM | | IHQVLIKQKC | | IVGFYILKTL | | LEGCCGEDII | | YMNENGEFKL |
| DVDSNAIIQD | | VKLLEELLLD | | WKIWSKAEQG | | VWETLLAALE | | VLIRADHHQQ |
| MFNIKQLLKA | | QVVHHFLLTC | | QVLQEYKEGQ | | LTPMPREVCR | | SFVKIIAEVL |
| GSPPDLELLT | | IIFNFLLAVH | | PPTNTYVCHN | | PTNFYFSLHI | | DGKIFQEKVR |
| SIMYLRHSSS | | GGRSLMSPGF | | MVISPSGFTA | | SPYEGENSSN | | IIPQQMAAHM |
| LRSRSLPAFP | | TSSLLTQSQK | | LTGSLGCSID | | RLQNIADTYV | | ATQSKKQNSL |
| GSSDTLKKGK | | EDAFISSCES | | AKTVCEMEAV | | LSAQVSVSDV | | PKGVLGFPVV |
| KADHKQLGAE | | PRSEDDSPGD | | ESCPRRPDYL | | KGLASFQRSH | | STIASLGLAF |
| PSQNGSAAVG | | RWPSLVDRNT | | DDWENFAYSL | | GYEPNYNRTA | | SAHSVTEDCL |
| VPICCGLYEL | | LSGVLLILPD | | VLLEDVMDKL | | IQADTLLVLV | | NHPSPAIQQG |
| VIKLLDAYFA | | RASKEQKDKF | | LKNRGFSLLA | | NQLYLHRGTQ | | ELLECFIEMF |
| FGRHIGLDEE | | FDLEDVRNMG | | LFQKWSVIPI | | LGLIETSLYD | | NILLHNALLL |
| LLQILNSCSK | | VADMLLDNGL | | LYVLCNTVAA | | LNGLEKNIPM | | SEYKLLACDI |
| QQLFIAVTIH | | ACSSSGSQYF | | RVIEDLIVML | | GYLQNSKNKR | | TQNMAVALQL |
| RVLQAAMEFI | | RTTANHDSEN | | LTDSLQSPSA | | PHHAVVQKRK | | SIAGPRKFPL |
| AQTESLLMKM | | RSVANDELHV | | MMQRRMSQEN | | PSQATETELA | | QRLQRLTVLA |
| VNRIIYQEFN | | SDIIDILRTP | | ENVTQSKTSV | | FQTEISEENI | | HHEQSSVFNP |
| FQKEIFTYLV | | EGFKVSIGSS | | KASGSKQQWT | | KILWSCKETF | | RMQLGRLLVH |
| ILSPAHAAQE | | RKQIFEIVHE | | PNHQEILRDC | | LSPSLQHGAK | | LVLYLSELIH |
| NHQGELTEEE | | LGTAELLMNA | | LKLCGHKCIP | | PSASTKADLI | | KMIKEEQKKY |
| ETEEGVNKAA | | WQKTVNNNQQ | | SLFQRLDSKS | | KDISKIAADI | | TQAVSLSQGN |
| ERKKVIQHIR | | GMYKVDLSAS | | RHWQELIQQL | | THDRAVWYDP | | IYYPTSWQLD |
| PTEGPNRERR | | RLQRCYLTIP | | NKYLLRDRQK | | SEDVVKPPLS | | YLFEDKTHSS |
| FSSTVKDKAA | | SESIRVNRRC | | ISVAPSRETA | | GELLLGKCGM | | YFVEDNASDT |
| VESSSLQGEL | | EPASFSWTYE | | EIKEVHKRWW | | QLRDNAVEIF | | LTNGRTLLLA |
| FDNTKVRDDV | | YHNILTNNLP | | NLLEYGNITA | | LTNLWYTGQI | | TNFEYLTHLN |
| KHAGRSFNDL | | MQYPVFPFIL | | ADYVSETLDL | | NDLLIYRNLS | | KPIAVQYKEK |
| EDRYVDTYKY | | LEEEYRKGAR | | EDDPMPPVQP | | YHYGSHYSNS | | GTVLHFLVRM |
| PPFTKMFLAY | | QDQSFDIPDR | | TFHSTNTTWR | | LSSFESMTDV | | KELIPEFFYL |
| PEFLVNREGF | | DFGVRQNGER | | VNHVNLPPWA | | RNDPRLFILI | | HRQALESDYV |
| SQNICQWIDL | | VFGYKQKGKA | | SVQAINVFHP | | ATYFGMDVSA | | VEDPVQRRAL |
| ETMIKTYGQT | | PRQLFHMAHV | | SRPGAKLNIE | | GELPAAVGLL | | VQFAFRETRE |
| QVKEITYPSP | | LSWIKGLKWG | | EYVGSPSAPV | | PVVCFSQPHG | | ERFGSLQALP |
| TRAICGLSRN | | FCLLMTYSKE | | QGVRSMNSTD | | IQWSAILSWG | | YADNILRLKS |
| KQSEPPVNFI | | QSSQQYQVTS | | CAWVPDSCQL | | FTGSKCGVIT | | AYTNRFTSST |
| PSEIEMETQI | | HLYGHTEEIT | | SLFVCKPYSI | | LISVSRDGTC | | IIWDLNRLCY |
| VQSLAGHKSP | | VTAVSASETS | | GDIATVCDSA | | GGGSDLRLWT | | VNGDLVGHVH |
| CREIICSVAF | | SNQPEGVSIN | | VIAGGLENGI | | VRLWSTWDLK | | PVREITFPKS |
| NKPIISLTFS | | CDGHHLYTAN | | SDGTVIAWCR | | KDQQRLKQPM | | FYSFLSSYAA |
| G |
Задіяний у таких біологічних процесах як транспорт, транспорт білків.
Локалізований у цитоплазмі.
Література
Примітки
Див. також
