美國西部(英語:Western United States、 American West)指的是美國西部各州。由於美國自建國以來疆域多次向西擴展,因此美國西部的定義也隨著時代而變化。一般多以密西西比河作為美國東西部的分界線。如果采用廣義的定義,美國西部占去了美國一半以上的領土。美國西部包括了自路易西安納購地中獲得的土地、1818年自英國獲得的土地、德克薩斯州加入美國時的土地、1846年自英國獲得的土地、1848年墨西哥割讓予美國的土地及蓋茲登購地中獲得的土地。
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