Share to: share facebook share twitter share wa share telegram print page

高剂量雌激素治疗

高剂量雌激素治疗(英語:High-dose estrogen therapy)是一种荷爾蒙療法,其中给予高剂量的雌激素[1] 当与高剂量的孕激素联合使用时,它被称为假孕[2][3][4][5] “假孕”的称呼来源于其达到的雌激素和孕激素水平与妊娠期间这些激素的高水平相当。[6] 它们被用于医学中一些激素依赖性的适应症的治疗,如乳癌前列腺癌子宮內膜異位症等。[1][7][2]

医学用途

可用药物

以下类固醇雌激素已用于高剂量雌激素治疗:[1][21][22]

以及以下非类固醇雌激素(现在很少或根本不使用):[21]己烯雌酚乙烯雌酚二磷酸酯英语Fosfestrol、Bifluranol及其他乙烯雌酚

用于假孕方案的孕激素包括己酸孕酮英语Hydroxyprogesterone caproate醋酸甲羟孕酮英语Medroxyprogesterone acetate醋酸环丙孕酮等。[2] 孕酮由于其不良的药代动力学(例如,低口服生物利用度和短半衰期)而很少用于这些目的。[23]

参见

参考资料

  1. ^ 1.0 1.1 1.2 1.3 Coelingh Bennink HJ, Verhoeven C, Dutman AE, Thijssen J. The use of high-dose estrogens for the treatment of breast cancer. Maturitas. January 2017, 95: 11–23. PMID 27889048. doi:10.1016/j.maturitas.2016.10.010可免费查阅. 
  2. ^ 2.0 2.1 2.2 Victor Gomel; Andrew Brill. Reconstructive and Reproductive Surgery in Gynecology. CRC Press. 27 September 2010: 90–. ISBN 978-1-84184-757-3. 
  3. ^ 3.0 3.1 3.2 Ulrich U, Pfeifer T, Lauritzen C. Rapid increase in lumbar spine bone density in osteopenic women by high-dose intramuscular estrogen-progestogen injections. A preliminary report. Hormone and Metabolic Research. September 1994, 26 (9): 428–31. PMID 7835827. doi:10.1055/s-2007-1001723. 
  4. ^ 4.0 4.1 Ulrich U, Pfeifer T, Buck G, Keckstein J, Lauritzen C. High-dose estrogen-progestogen injections in gonadal dysgenesis, ovarian hypoplasia, and androgen insensitivity syndrome: Impact on bone density. Adolescent and Pediatric Gynecology. 1995, 8 (1): 20–23. ISSN 0932-8610. doi:10.1016/S0932-8610(12)80156-3. 
  5. ^ Kistner RW. The Treatment of Endometriosis by Inducing Pseudopregnancy with Ovarian Hormones. Fertility and Sterility. 1959, 10 (6): 539–556. ISSN 0015-0282. doi:10.1016/S0015-0282(16)33602-0. 
  6. ^ Kenneth L. Becker. Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. 2001: 1059–1060. ISBN 978-0-7817-1750-2. 
  7. ^ 7.0 7.1 Oh WK. The evolving role of estrogen therapy in prostate cancer. Clinical Prostate Cancer. September 2002, 1 (2): 81–9. PMID 15046698. doi:10.3816/cgc.2002.n.009. 
  8. ^ Lycette JL, Bland LB, Garzotto M, Beer TM. Parenteral estrogens for prostate cancer: can a new route of administration overcome old toxicities?. Clinical Genitourinary Cancer. December 2006, 5 (3): 198–205. PMID 17239273. doi:10.3816/CGC.2006.n.037. 
  9. ^ Turo R, Smolski M, Esler R, Kujawa ML, Bromage SJ, Oakley N, et al. Diethylstilboestrol for the treatment of prostate cancer: past, present and future. Scandinavian Journal of Urology. February 2014, 48 (1): 4–14. PMID 24256023. S2CID 34563641. doi:10.3109/21681805.2013.861508. 
  10. ^ Berkowitz RS, Barbieri RL, Kistner RW, Ryan KJ. Kistner's Gynecology: Principles and Practice. Mosby. 1995: 263. ISBN 978-0-8151-7479-0. Hormonal therapy. During the past 40 years, the medical management of endometriosis has become significantly more sophisticated. In the early 1950s the high-dose estrogen regimen of Karnaky was the only available hormonal treatment for endometriosis. In the 1960s and 1970s, Kistner's "pseudopregnancy" and "progestin-only" regimens dominated the medical management of endometriosis.69 During the 1980s, danazol became the primary hormonal agent used in the treatment of endometriosis. In the 1990s the GnRH agonists have become the most frequently used drugs for the treatment of endometriosis. These advances have significantly expanded the hormonal armamentarium of the gynecologist when treating endometriosis. 
  11. ^ Albuquerque EV, Scalco RC, Jorge AA. Management of Endocrine Disease: Diagnostic and therapeutic approach of tall stature. European Journal of Endocrinology. June 2017, 176 (6): R339–R353. PMID 28274950. doi:10.1530/EJE-16-1054可免费查阅. 
  12. ^ Duarte FH, Jallad RS, Bronstein MD. Estrogens and selective estrogen receptor modulators in acromegaly. Endocrine. November 2016, 54 (2): 306–314. PMID 27704479. S2CID 10136018. doi:10.1007/s12020-016-1118-z. 
  13. ^ Smith KP, Madison CM, Milne NM. Gonadal suppressive and cross-sex hormone therapy for gender dysphoria in adolescents and adults. Pharmacotherapy. December 2014, 34 (12): 1282–97. PMID 25220381. S2CID 26979177. doi:10.1002/phar.1487. 
  14. ^ Mueller A, Dittrich R, Binder H, Kuehnel W, Maltaris T, Hoffmann I, Beckmann MW. High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing hormone agonist in the absence of testosterone. European Journal of Endocrinology. July 2005, 153 (1): 107–13. PMID 15994752. doi:10.1530/eje.1.01943可免费查阅. 
  15. ^ Gunther Göretzlehner; Christian Lauritzen; Thomas Römer; Winfried Rossmanith. Praktische Hormontherapie in der Gynäkologie. Walter de Gruyter. 1 January 2012: 385–. ISBN 978-3-11-024568-4. 
  16. ^ Hartmann BW, Laml T, Kirchengast S, Albrecht AE, Huber JC. Hormonal breast augmentation: prognostic relevance of insulin-like growth factor-I. Gynecological Endocrinology. April 1998, 12 (2): 123–7. PMID 9610425. doi:10.3109/09513599809024960. 
  17. ^ Kaiser R. [Therapeutic pseudopregnancy]. Geburtshilfe und Frauenheilkunde. July 1959, 19: 593–604. PMID 13853204 (德语). 
  18. ^ Cronje WH, Studd JW. Premenstrual syndrome and premenstrual dysphoric disorder. Primary Care. March 2002, 29 (1): 1–12, v. PMID 11856655. doi:10.1016/s0095-4543(03)00070-8. 
  19. ^ Gentile S. The role of estrogen therapy in postpartum psychiatric disorders: an update. CNS Spectrums. December 2005, 10 (12): 944–52. PMID 16344831. S2CID 24450591. doi:10.1017/s1092852900010518. 
  20. ^ Sharma V. Pharmacotherapy of postpartum psychosis. Expert Opinion on Pharmacotherapy. October 2003, 4 (10): 1651–8. PMID 14521476. S2CID 23193276. doi:10.1517/14656566.4.10.1651. 
  21. ^ 21.0 21.1 Christoffel Jos van Boxtel; Budiono Santoso; I. Ralph Edwards. Drug Benefits and Risks: International Textbook of Clinical Pharmacology. IOS Press. 2008: 458–. ISBN 978-1-58603-880-9. 
  22. ^ Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. 6 December 2012: 540–. ISBN 978-3-642-60107-1. 
  23. ^ Roy G. Farquharson; Mary D. Stephenson. Early Pregnancy. Cambridge University Press. 2 February 2017: 259–. ISBN 978-1-107-08201-4. 

Read other articles:

Keuskupan Rouyn–NorandaKatolik Cathédrale Saint-JosephLokasiNegaraKanadaProvinsi gerejawiQuebecPopulasi- Katolik58,900 (97.4%)InformasiDenominasiKatolik RomaRitusRitus RomaKatedralCathédrale Saint-JosephKepemimpinan kiniPausFransiskusUskupJoseph Ferdinand Guy BoulangerSitus webhttp://diocese-rouyn-noranda.org Keuskupan Rouyn–Noranda (bahasa Latin: Dioecesis Ruynensis–Norandensis) adalah sebuah keuskupan Katolik Roma yang meliputi bagian dari Provinsi Quebec. Keuskupan …

Cronulla-Sutherland Sharks Informasi klub Nama penuh Cronulla SutherlandDistrict Rugby LeagueFootball Club Ltd Nama panggil Sharks, The Shire, Sharkies Didirikan 1963 dengan nama Cronulla-Caringbah 1967 di New South Wales Rugby League Detail terkini Lapangan Toyota Park (22.500) CEO Richard Fisk Kompetisi National Rugby League 2009 ke-15 Musim terkini Records Kejuaraan 0 Runner-up 3 (1973, 1978, 1997) Kejuaraan kecil 2 (1988, 1999) Cronulla-Sutherland Sharks adalah sebuah tim liga rugbi profesio…

Adriani ElisabethLisa tahun 2019Lahir10 Mei 2000 (umur 23)Purbalingga, Jawa Tengah, IndonesiaPekerjaanIdolDikenal atasPeringkat 4 (Senbatsu) — JKT48 Janken Competition 2016Karier musikGenrePopJ-PopInstrumenVokalTahun aktif2015 - 2021LabelHits RecordsDentsuX EntertainmentArtis terkaitJKT48Situs webJKT48AnggotaJKT48 (2015 - 2021) Adriani Elisabeth (lahir 10 Mei 2000) yang sebelumnya di kenal sebagai Lisa JKT48 adalah seorang penyanyi dan penari yang bergabung dalam idol grup JKT48 asal Indo…

Cet article est une ébauche concernant le modélisme, le maquettisme et les modèles réduits et un bateau ou un navire. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. En 1898, Tesla fait la démonstration d’un bateau radiocommandé (en) Brevet U.S. 613,809   - Méthode d'un appareil de contrôle du mécanisme d'un véhicule ou de véhicules en mouvement. Un bateau radiocommandé est un bateau contrôlé à…

Disambiguazione – Se stai cercando altri significati, vedi Maryland (disambigua). Marylandstato federato(EN) State of Maryland (dettagli) (dettagli) Maryland – VedutaBaltimora LocalizzazioneStato Stati Uniti AmministrazioneCapoluogoAnnapolis GovernatoreWes Moore (D) dal 2023 Data di istituzione28 aprile 1788 TerritorioCoordinatedel capoluogo38°58′22″N 76°30′17″W / 38.972778°N 76.504722°W38.972778; -76.504722 (Maryland)Coordinate: 38°58′22″…

Sporting event delegationNiger at the2011 World Aquatics ChampionshipsFlag of NigerFINA codeNIGNational federationFederation Nigerienne des Sport Nautiquesin Shanghai, ChinaCompetitors3 in 1 sportMedals Gold 0 Silver 0 Bronze 0 Total 0 World Aquatics Championships appearances197319751978198219861991199419982001200320052007200920112013201520172019202220232024 Niger competed at the 2011 World Aquatics Championships in Shanghai, China between July 16 and 31, 2011. Swimming Main article: Swimming at…

Bagian dari seri mengenai Sejarah Israel Israel kuno dan Yudea Prasejarah Kanaan Bangsa Israel Monarki persatuan Kerajaan Utara Kerajaan Yudea Pemerintahan Babilonia Zaman Bait Allah Kedua (530 SM–70 M) Pemerintahan Persia Pemerintahan Helenistik Dinasti Hasmonean Kerajaan Herodian Tetrarki Yudea Romawi Abad Pertengahan (70–1517) Palaestina Romawi Palaestina Bizantium (Prima · Secunda) Penaklukan Sasaniyah Kekhalifahan (Filastin · Urdunn) Perang Salib Dinasti Ayyubiyyah Kesultanan Mamluk K…

Railway station in Sydney, New South Wales, Australia TurrellaWestbound view of platform, building and shelter, December 2011General informationLocationTurrella Street, TurrellaCoordinates33°55′48″S 151°08′24″E / 33.92994722°S 151.1399472°E / -33.92994722; 151.1399472Owned byTransport Asset Holding EntityOperated bySydney TrainsLine(s)East HillsDistance8.63 kilometres from CentralPlatforms2 (1 island)Tracks4ConnectionsBusConstructionStructure typeGroundAccessi…

Style of stained glass design in 12th to 16th century England English Gothic stained glass windowsDetail of a Tree of Jesse Window from Canterbury Cathedral (late 12th–early 13th c.)Years active12th to 17th centuryLocationEngland English Gothic stained glass windows were an important feature of English Gothic architecture, which appeared between the late 12th and late 16th centuries. They evolved from narrow windows filled with a mosaic of deeply-coloured pieces of glass into gigantic windows …

Coppa di Portogallo 1957-1958Taça de Portugal 1957-1958 Competizione Taça de Portugal Sport Calcio Edizione 18ª Date dal 30 marzo 1958al 15 giugno 1958 Luogo  Portogallo Partecipanti 17 Sede finale Stadio nazionale di Jamor Risultati Vincitore  Porto(2º titolo) Secondo  Benfica Semi-finalisti  Sporting Lisbona Barreirense Statistiche Incontri disputati 31 Gol segnati 107 (3,45 per incontro) Cronologia della competizione 1956-1957 1958-1959 Manuale La Ta…

此條目可参照英語維基百科相應條目来扩充。 (2021年5月6日)若您熟悉来源语言和主题,请协助参考外语维基百科扩充条目。请勿直接提交机械翻译,也不要翻译不可靠、低品质内容。依版权协议,译文需在编辑摘要注明来源,或于讨论页顶部标记{{Translated page}}标签。 约翰斯顿环礁Kalama Atoll 美國本土外小島嶼 Johnston Atoll 旗幟颂歌:《星條旗》The Star-Spangled Banner約翰斯頓環礁地…

  سرقسطة (بالإسبانية: Zaragoza)‏[1]    سرقسطة سرقسطة تقسيم إداري البلد إسبانيا  [2][3] العاصمة سرقسطة  [لغات أخرى]‏  عاصمة لـ أَرَغـُونسرقسطة  خصائص جغرافية إحداثيات 41°39′00″N 0°53′00″W / 41.65°N 0.88333333333333°W / 41.65; -0.88333333333333   [4] المساحة 97…

SadmaPosterSutradaraBalu MahendraProduserRaj N. Sippy Romu N. SippySkenario Balu Mahendra Gulzar (dialog) CeritaBalu MahendraPemeran Kamal Haasan Sridevi Gulshan Grover Silk Smitha Penata musikIlaiyaraajaSinematograferBalu MahendraPenyuntingD. VasuTanggal rilis 8 Juli 1983 (1983-07-08) Durasi141 menNegaraIndiaBahasaHindi Sadma (Hindi: सदमा; bahasa Inggris: Trauma) adalah sebuah film drama percintaan berbahasa Hindi India 1983, yang ditulis, disutradarai dan difilmkan o…

American governmental official This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Theodore Roosevelt III – news · newspapers · books · scholar · JSTOR (March 2014) (Learn how and when to remove this message) Theodore Roosevelt IIISecretary of Commerce of PennsylvaniaIn office1949–1951 Personal detailsBornTheodor…

State electoral district of New South Wales, Australia Australian electorate HeffronNew South Wales—Legislative AssemblyInteractive map of district boundaries from the 2023 state electionStateNew South WalesDates current1973–presentMPRon HoenigPartyLabor PartyNamesakeBob HeffronElectors60,576 (2019)Area35.28 km2 (13.6 sq mi)DemographicInner-Metropolitan Electorates around Heffron: Summer Hill Newtown Sydney Canterbury Heffron Coogee Rockdale Maroubra Maroubra Heffron is a…

The Warehouse Studio in Vancouver's Gastown. The Warehouse Studio è uno studio di registrazione e studio fotografico che si trova a Vancouver, Columbia Britannica, Canada di proprietà del cantante rock canadese Bryan Adams.[1] [2][3][4] Indice 1 La costruzione 2 Gli studi 2.1 Studio 1 - SSL 4072 G + 2.2 Studio 2 - Neve A6630 2.3 Neve A6630 console 2.4 Studio 3 - SSL 9080 J 2.5 Studio 4 2.6 Unità mobile 3 Registrazioni celebri 4 Produttori e ingegneri 5 Note 6 C…

Para otros usos de este término, véase Iglesia de Santa María del Mar. Basílica de Santa María del Mar bien de interés cultural y Bien Cultural de Interés Nacional LocalizaciónPaís España EspañaComunidad Cataluña CataluñaLocalidad  BarcelonaCoordenadas 41°23′01″N 2°10′55″E / 41.383611, 2.181944Información religiosaCulto Iglesia católicaDiócesis BarcelonaAdvocación Santa MaríaPatrono Virgen MaríaHistoria del edificioFundación 1329Constr…

American politician (1955–2021) Doug GreenMember of the Ohio House of Representativesfrom the 66th districtIn officeJanuary 7, 2013 – December 31, 2020Preceded byDanny BubpSucceeded byAdam Bird Personal detailsBornAugust 22, 1955DiedSeptember 1, 2021(2021-09-01) (aged 66)Political partyRepublicanResidence(s)Mt. Orab, Ohio, U.S. Doug Green (August 22, 1955 – September 1, 2021)[1] was an American politician. He was a Republican member of the Ohio House of Re…

UCL Faculty of LawsEstablished1827Parent institutionUniversity College LondonDeanProf. Eloise ScotfordAdministrative staff150Undergraduates650Postgraduates390LocationBentham House, London, United KingdomWebsitewww.ucl.ac.uk/laws The UCL Faculty of Laws is the law school of University College London (UCL), itself part of the federal University of London. It is one of UCL's 11 constituent faculties and is based in London, United Kingdom.[1] It is one of the world's leading law schools,[…

Battle of XichengPart of the Ming-Qing transitionDateSeptember 1619LocationXicheng, China (modern Lishu County, Jilin province)Result Later Jin victoryBelligerents Later Jin Yehe JurchensMing dynastyCommanders and leaders Nurhaci GintaisiStrength unknown unknownCasualties and losses unknown unknown vteMing−Qing transition Belligerents Ming Southern Ming Tungning Qing Later Jin Peasant rebellions Shun Xi She–An Rebellion Battles Fushun Qinghe Sarhū Kaiyuan Tieling Xicheng Chahar Shen-Liao Zh…

Kembali kehalaman sebelumnya