鸭嘴花碱酮

鸭嘴花碱酮
	IUPAC名; (1S)-1-Hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-5(1H)-one
识别
CAS号	486-64-6
PubChem	442935
ChemSpider	391238
SMILES	C1CN2C(=NC3=CC=CC=C3C2=O)[C@H]1O;
ChEBI	9936
性质
化学式	C11H10N2O2
摩尔质量	202.21 g·mol−1
密度	1.5 g/cm3
熔点	200 - 202 °C（271 K）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

鸭嘴花碱酮（英語：Vasicinone）是一种喹唑啉生物碱。它在体外显示出支气管扩张作用，^[1]但在体内显示出支气管收缩作用。^[2]鸭嘴花碱酮被证明具有抗过敏作用。^[3]它是在骆驼蓬中发现的。^[4]

鸭嘴花碱酮与类似物鸭嘴花碱的组合也被进行了研究。两种生物碱的组合（1:1）在体内和体外均显示出显着的支气管扩张活性。^[5]这两种生物碱也是呼吸兴奋剂。^[5]鸭嘴花碱具有心脏抑制作用，鸭嘴花碱酮是一种弱心脏兴奋剂；通过结合这两种生物碱可以使效果正常化。^[5]^[3]据报道，鸭嘴花碱具有子宫兴奋作用。^[3]

参考资料

^ Amin, A. H.; Mehta, D. R. A Bronchodilator Alkaloid (Vasicinone) from Adhatoda vasica Nees. Nature. 1959, 184 (4695): 1317. Bibcode:1959Natur.184.1317A. ISSN 0028-0836. PMID 13793186. doi:10.1038/1841317a0 .
^ Mehta, D. R.; Naravane, J. S.; Desai, R. M. Vasicinone. A Bronchodilator Principle from Adhatoda Vasica Nees (N. O. Acanthaceae). The Journal of Organic Chemistry. 1963, 28 (2): 445–448. ISSN 0022-3263. doi:10.1021/jo01037a041.
^ ^3.0 ^3.1 ^3.2 Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian Journal of Pharmaceutical Sciences. 2008, 70 (1): 36–42. ISSN 0250-474X. PMC 2852058 . PMID 20390078. doi:10.4103/0250-474X.40329 .
^ Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. July 2013, 7 (14): 199–212. PMC 3841998 . PMID 24347928. doi:10.4103/0973-7847.120524 .
^ ^5.0 ^5.1 ^5.2 Avula, B.; et al. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis (PDF). Die Pharmazie. 2008, 63 (1): 20–22. PMID 18271297. doi:10.1691/ph.2008.7175.

[AminMehta1959-1] Amin, A. H.; Mehta, D. R. A Bronchodilator Alkaloid (Vasicinone) from Adhatoda vasica Nees. Nature. 1959, 184 (4695): 1317. Bibcode:1959Natur.184.1317A. ISSN 0028-0836. PMID 13793186. doi:10.1038/1841317a0 .

[MehtaNaravane1963-2] Mehta, D. R.; Naravane, J. S.; Desai, R. M. Vasicinone. A Bronchodilator Principle from Adhatoda Vasica Nees (N. O. Acanthaceae). The Journal of Organic Chemistry. 1963, 28 (2): 445–448. ISSN 0022-3263. doi:10.1021/jo01037a041.

[RajaniSoni2008-3] 3.0 ^3.1 ^3.2 Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian Journal of Pharmaceutical Sciences. 2008, 70 (1): 36–42. ISSN 0250-474X. PMC 2852058 . PMID 20390078. doi:10.4103/0250-474X.40329 .

[4] Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. July 2013, 7 (14): 199–212. PMC 3841998 . PMID 24347928. doi:10.4103/0973-7847.120524 .

[avula2008-5] 5.0 ^5.1 ^5.2 Avula, B.; et al. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis (PDF). Die Pharmazie. 2008, 63 (1): 20–22. PMID 18271297. doi:10.1691/ph.2008.7175.

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鸭嘴花碱酮

参考资料

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