「
帕金森综合症 」重定向至此。关于其他用法,请见「
帕金森氏症 」。
帕金森症候群 (Parkinsonism)是和運動機能相關的臨床症候群 ,其特徵是顫抖 、運動功能減退 、僵硬 及平衡障礙 [ 1] [ 2] 。在帕金森氏症 (PD)患者身上會有類似症狀(此症候群因此而得名),而路易氏體失智症 (DLB)、帕金森病性失智症 (PDD)等疾病也會有此症狀。這類症候群的病因範圍很廣,包括神經退化障礙 疾病、藥物、毒素 、代謝疾病 ,或是帕金森氏症以外的神經性疾病[ 3] 。
病因
藥物引起
有帕金森症候群的人當中,約有7%是因為藥物的副作用而造成的,主要是因為抗精神病药 ,特別是吩噻嗪 (例如perphenazine及氯丙嗪 )、噻噸 (例如三氟噻噸 及珠氯噻醇 )及丁酰苯 (例如氟哌啶醇 ),偶爾也有因為抗憂鬱藥物而造成。藥物引起帕金森症候群的盛行率會隨年齡而上昇。藥物引起的帕金森症候群一但出現,多半會維持原有的程度,不像帕金森氏症會漸漸惡化[ 4] 。
毒素
有發現殺蟲劑或除草劑暴露程度和帕金森氏症之間的關聯性。若暴露在百草枯 或錳乃浦 /鋅錳乃浦 下,風險是原來的兩倍[ 5] 。
已證實慢性锰 (Mn)暴露會造成類似帕金森症候群的疾病,其特徵是運動障礙,此症狀無法用典型的帕金森症治療方式 來治療,因此推測除了典型黑质 內多巴胺 能損失外,包括有其他的致病途徑[ 6] 。锰會在基底核 內累積,因此造成運動障礙[ 7] 有一種和SLC30A10基因(錳外流轉運蛋白,減少細胞內錳所必需的蛋白)有關的變異和這種類似帕金森症候群疾病有關[ 8] 。在這疾病中看不到帕金森氏症中典型的路易體 [ 7] 。
診斷
許多疾病會造成帕金森症候群。
神經退化障礙 及巴金森附加症候群 [ 9]
藥物引發(偽帕金森症候群)
感染
毒素
創傷
血管的
其他
原發性震顫
根據2018年的回顧性研究,還不確定帕金森症候群和原發性震顫 是否有關[ 30] 。
參考資料
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外部連結