ADAMTS8
| ADAMTS8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Pengidentifikasi | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Alias | ADAMTS8, ADAM-TS8, METH2, ADAM metallopeptidase with thrombospondin type 1 motif 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| ID Eksternal | OMIM: 605175; MGI: 1353468; HomoloGene: 5108; GeneCards: ADAMTS8; OMA:ADAMTS8 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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A disintegrin and metalloproteinase with thrombospondin motifs 8 adalah enzim yang pada manusia disandi oleh gen ADAMTS8.[3][4]
Fungsi
Gen ini menyandi anggota keluarga protein ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs). Anggota keluarga ini berbagi beberapa modul protein yang berbeda, termasuk daerah propeptida, domain metalloproteinase, domain seperti disintegrin, dan motif thrombospondin tipe 1 (TS). Anggota individu dari keluarga ini berbeda dalam jumlah motif TS C-terminal, dan beberapa memiliki domain C-terminal yang unik. Enzim yang disandi oleh gen ini mengandung dua motif TS C-terminal, dan mengganggu angiogenesis secara in vivo.[4]
Signifikansi klinis
Sejumlah kelainan telah dipetakan di sekitar gen ini, terutama neoplasma paru-paru.[4]
Referensi
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
- ^ a b c "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8".
Bacaan lebih lanjut
- Wågsäter D, Björk H, Zhu C, et al. (2008). "ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques". Atherosclerosis. 196 (2): 514–22. doi:10.1016/j.atherosclerosis.2007.05.018. PMID 17606262.
- Dunn JR, Reed JE, du Plessis DG, et al. (2006). "Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours". Br. J. Cancer. 94 (8): 1186–93. doi:10.1038/sj.bjc.6603006. PMC 2361255. PMID 16570050.
- Porter S, Span PN, Sweep FC, et al. (2006). "ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma". Int. J. Cancer. 118 (5): 1241–7. doi:10.1002/ijc.21476. PMID 16152618. S2CID 20711295.
- Dunn JR, Panutsopulos D, Shaw MW, et al. (2004). "METH-2 silencing and promoter hypermethylation in NSCLC". Br. J. Cancer. 91 (6): 1149–54. doi:10.1038/sj.bjc.6602107. PMC 2747718. PMID 15328519.
- Collins-Racie LA, Flannery CR, Zeng W, et al. (2005). "ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage". Matrix Biol. 23 (4): 219–30. doi:10.1016/j.matbio.2004.05.004. PMID 15296936.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Georgiadis KE, Hirohata S, Seldin MF, Apte SS (2000). "ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11". Genomics. 62 (2): 312–5. doi:10.1006/geno.1999.6014. PMID 10610729.
Pranala luar
- Basis data daring MEROPS untuk peptidase dan inhibitornya: M12.226
- Lokasi genom ADAMTS8 manusia dan halaman rincian gen ADAMTS8 dalam UCSC Genome Browser.
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