Alcohol dehydrogenase 1C adalah sebuah enzim yang pada manusia disandikan oleh genADH1C.[4]
Fungsi
Gen ini menyandikan alkohol dehidrogenase kelas I, subunit gamma, yang merupakan anggota keluarga alkohol dehidrogenase. Anggota keluarga enzim ini memetabolisme berbagai macam substrat, termasuk etanol (alkohol minuman), retinol, alkohol alifatik lainnya, hidroksisteroid, dan produk peroksidasi lipid. Alkohol dehidrogenase kelas I, yang terdiri dari beberapa homodimer dan heterodimer dari subunit alfa, beta, dan gamma, menunjukkan aktivitas tinggi untuk oksidasi etanol dan memainkan peran utama dalam katabolisme etanol. Tiga gen yang menyandikan subunit alfa, beta, dan gamma disusun secara tandem dalam segmen genom sebagai gugus gen.[5]
Seitz HK, Meier P (Jun 2007). "The role of acetaldehyde in upper digestive tract cancer in alcoholics". Translational Research. 149 (6): 293–7. doi:10.1016/j.trsl.2006.12.002. PMID17543846.
Stewart MJ, McBride MS, Winter LA, Duester G (Jun 1990). "Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box". Gene. 90 (2): 271–9. doi:10.1016/0378-1119(90)90190-3. PMID2169444.
Yasunami M, Kikuchi I, Sarapata D, Yoshida A (Jun 1990). "The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome". Genomics. 7 (2): 152–8. doi:10.1016/0888-7543(90)90535-3. PMID2347582.
Tsukahara M, Yoshida A (Feb 1989). "Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization". Genomics. 4 (2): 218–20. doi:10.1016/0888-7543(89)90304-2. PMID2737681.
Xu YL, Carr LG, Bosron WF, Li TK, Edenberg HJ (Apr 1988). "Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification". Genomics. 2 (3): 209–14. doi:10.1016/0888-7543(88)90004-3. PMID3397059.
Cheung C, Smith CK, Hoog JO, Hotchkiss SA (Jul 1999). "Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin". Biochemical and Biophysical Research Communications. 261 (1): 100–7. Bibcode:1999BBRC..261..100C. doi:10.1006/bbrc.1999.0943. PMID10405330.
Duester G, Farrés J, Felder MR, Holmes RS, Höög JO, Parés X, Plapp BV, Yin SJ, Jörnvall H (Aug 1999). "Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family". Biochemical Pharmacology. 58 (3): 389–95. doi:10.1016/S0006-2952(99)00065-9. PMID10424757.
Osier MV, Pakstis AJ, Goldman D, Edenberg HJ, Kidd JR, Kidd KK (Dec 2002). "A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans". Alcoholism: Clinical and Experimental Research. 26 (12): 1759–63. doi:10.1111/j.1530-0277.2002.tb02481.x. PMID12500098.
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