ATP11C

ATP11C
Pengidentifikasi
AliasATP11C, ATPIG, ATPIQ, ATPase phospholipid transporting 11C, HACXL
ID EksternalOMIM: 300516; MGI: 1859661; HomoloGene: 27862; GeneCards: ATP11C; OMA:ATP11C - orthologs
Nomor EC7.6.2.1
Ortologi
SpesiesManusiaTikus
Entrez

286410

320940

Ensembl

ENSG00000101974

ENSMUSG00000062949

UniProt

Q8NB49

Q9QZW0

RefSeq (mRNA)

NM_001010986
NM_173694
NM_001353810
NM_001353811
NM_001353812

NM_001001798
NM_001037863
NM_001359002

RefSeq (protein)

NP_001010986
NP_775965
NP_001340739
NP_001340740
NP_001340741

NP_001001798
NP_001032952
NP_001345931

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
Lihat/Sunting ManusiaLihat/Sunting Tikus

ATP11C adalah enzim yang pada manusia disandikan oleh gen ATP11C.

Fungsi

ATP11C menyandikan anggota keluarga ATPase tipe-P Tipe IV yang diperkirakan mentranspor atau 'membalik' aminofosfolipid. Protein terkait pada mencit sangat penting untuk perkembangan sel B dan sel darah merah,[3][4] serta untuk pencegahan kolestasis intrahepatik.[5]

Referensi

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC 3079768. PMID 21423172.
  4. ^ Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC 3272780. PMID 21423173.
  5. ^ Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. Bibcode:2011PNAS..108.7890S. doi:10.1073/pnas.1104631108. PMC 3093471. PMID 21518881.


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