ETS
| Ets-domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Struktur autoinhibisi pengikatan DNA Ets-1.[1] | |||||||||
| Identifikasi | |||||||||
| Simbol | Ets | ||||||||
| Pfam | PF00178 | ||||||||
| Klan Pfam | CL0123 | ||||||||
| InterPro | IPR000418 | ||||||||
| SMART | SM00413 | ||||||||
| PROSITE | PDOC00374 | ||||||||
| SCOP | 1r36 | ||||||||
| SUPERFAMILY | 1r36 | ||||||||
| |||||||||
ETS (bahasa Inggris: E26 transformation-specific) adalah sekelompok faktor transkripsi yang mengatur diferensiasi, respon terhadap hormon dan lintasan tumorigenesis pada sejumlah organ endokrin dan jaringan tubuh.[2]
Ets-1, salah satu anggota ETS, merupakan protein yang langsung mengatur banyak gen penting pada lintasan angiogenesis dan extracellular matrix remodeling, seperti MMP-1, MMP-3, MMP-9, uPA, dan integrin-β3.[3] MAPK merupakan enzim akan mengaktivasi Ets-1 dan Ets-2.[4]
Rujukan
- ^ Lee GM, Donaldson LW, Pufall MA, et al. (February 2005). "The structural and dynamic basis of Ets-1 DNA binding autoinhibition". J. Biol. Chem. 280 (8): 7088–99. doi:10.1074/jbc.M410722200. PMID 15591056.
- ^ (Inggris) "ETS transcription factors in endocrine systems". University of Colorado HSC; Gutierrez-Hartmann A, Duval DL, Bradford AP. Diakses tanggal 2011-07-23.
- ^ (Inggris) "Ets-1 Regulates Energy Metabolism in Cancer Cells". Department of Research, Juravinski Cancer Centre, Department of Medical Science, Department of Pathology and Molecular Medicine,McMaster University, Duke University; Meghan L. Verschoor, Leigh A. Wilson, Chris P. Verschoor, dan Gurmit Singh. Diakses tanggal 2011-07-23.
- ^ (Inggris) "Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment". Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah; Foulds CE, Nelson ML, Blaszczak AG, Graves BJ. Diakses tanggal 2011-07-23.
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