INHA
Inhibin, alfa, juga dikenal sebagai INHA, adalah protein yang pada manusia dikodekan oleh gen INHA.[3]
Fungsi
Subunit inhibin-alfa bergabung dengan subunit beta A atau beta B untuk membentuk penghambat sekresi FSH hipofisis. Inhibin telah terbukti mengatur proliferasi sel stroma gonad secara negatif dan memiliki aktivitas penekan tumor. Selain itu, kadar serum inhibin telah terbukti mencerminkan ukuran tumor sel granulosa dan oleh karena itu dapat digunakan sebagai penanda untuk penyakit primer maupun rekuren.
Namun, pada kanker prostat, ekspresi gen subunit inhibin-alfa ditekan dan tidak terdeteksi pada sel tumor yang berdiferensiasi buruk. Selain itu, karena ekspresi dalam gonad dan berbagai jaringan ekstragonad dapat bervariasi beberapa kali lipat dengan cara yang spesifik untuk jaringan tertentu, diusulkan bahwa inhibin mungkin merupakan faktor pertumbuhan/diferensiasi dan hormon.[4]
Lihat pula
Referensi
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.
- ^ "Entrez Gene: INHA inhibin, alpha".
Bacaan lebih lanjut
- Mellor SL, Richards MG, Pedersen JS, et al. (1998). "Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer". J. Clin. Endocrinol. Metab. 83 (3): 969–75. doi:10.1210/jcem.83.3.4640. PMID 9506758.
- Munz B, Hübner G, Tretter Y, et al. (1999). "A novel role of activin in inflammation and repair". J. Endocrinol. 161 (2): 187–93. doi:10.1677/joe.0.1610187. PMID 10320815.
- Welt C, Sidis Y, Keutmann H, Schneyer A (2002). "Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium". Exp. Biol. Med. (Maywood). 227 (9): 724–52. doi:10.1177/153537020222700905. PMID 12324653. S2CID 19795772.
- Shav-Tal Y, Zipori D (2003). "The role of activin a in regulation of hemopoiesis". Stem Cells. 20 (6): 493–500. doi:10.1634/stemcells.20-6-493. PMID 12456957. S2CID 36242096.
- Shao L, Frigon NL, Young AL, et al. (1992). "Effect of activin A on globin gene expression in purified human erythroid progenitors". Blood. 79 (3): 773–81. doi:10.1182/blood.V79.3.773.bloodjournal793773. PMID 1310063.
- Vannelli GB, Barni T, Forti G, et al. (1992). "Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study". Cell Tissue Res. 269 (2): 221–7. doi:10.1007/bf00319612. PMID 1423490.
- Matzuk MM, Finegold MJ, Su JG, et al. (1992). "Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice". Nature. 360 (6402): 313–9. Bibcode:1992Natur.360..313M. doi:10.1038/360313a0. PMID 1448148. S2CID 4327163.
- Shimonaka M, Inouye S, Shimasaki S, Ling N (1991). "Follistatin binds to both activin and inhibin through the common subunit". Endocrinology. 128 (6): 3313–5. doi:10.1210/endo-128-6-3313. PMID 2036994.
- Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990). "Activin B: precursor sequences, genomic structure and in vitro activities". Mol. Endocrinol. 3 (9): 1352–8. doi:10.1210/mend-3-9-1352. PMID 2575216.
- Barton DE, Yang-Feng TL, Mason AJ, et al. (1989). "Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice". Genomics. 5 (1): 91–9. doi:10.1016/0888-7543(89)90091-8. PMID 2767687.
- Lappöhn RE, Burger HG, Bouma J, et al. (1989). "Inhibin as a marker for granulosa-cell tumors". N. Engl. J. Med. 321 (12): 790–3. doi:10.1056/NEJM198909213211204. PMID 2770810.
- Mayo KE, Cerelli GM, Spiess J, et al. (1986). "Inhibin A-subunit cDNAs from porcine ovary and human placenta". Proc. Natl. Acad. Sci. U.S.A. 83 (16): 5849–53. Bibcode:1986PNAS...83.5849M. doi:10.1073/pnas.83.16.5849. PMC 386393. PMID 3016724.
- Ramasharma K, Li CH (1987). "Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes". Proc. Natl. Acad. Sci. U.S.A. 84 (11): 3595–8. Bibcode:1987PNAS...84.3595R. doi:10.1073/pnas.84.11.3595. PMC 304921. PMID 3035540.
- Murata M, Eto Y, Shibai H, et al. (1988). "Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain". Proc. Natl. Acad. Sci. U.S.A. 85 (8): 2434–8. Bibcode:1988PNAS...85.2434M. doi:10.1073/pnas.85.8.2434. PMC 280011. PMID 3267209.
- Burger HG, Igarashi M (1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.
- Mason AJ, Niall HD, Seeburg PH (1986). "Structure of two human ovarian inhibins". Biochem. Biophys. Res. Commun. 135 (3): 957–64. doi:10.1016/0006-291X(86)91021-1. PMID 3754442.
- Stewart AG, Milborrow HM, Ring JM, et al. (1986). "Human inhibin genes. Genomic characterisation and sequencing". FEBS Lett. 206 (2): 329–34. doi:10.1016/0014-5793(86)81006-7. PMID 3758355. S2CID 21261385.
- Xu J, McKeehan K, Matsuzaki K, McKeehan WL (1995). "Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism". J. Biol. Chem. 270 (11): 6308–13. doi:10.1074/jbc.270.11.6308. PMID 7890768.
- Nishihara T, Okahashi N, Ueda N (1994). "Activin A induces apoptotic cell death". Biochem. Biophys. Res. Commun. 197 (2): 985–91. doi:10.1006/bbrc.1993.2576. PMID 8267637.
- Mason AJ, Farnworth PG, Sullivan J (1997). "Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A". Mol. Endocrinol. 10 (9): 1055–65. doi:10.1210/mend.10.9.8885240. PMID 8885240.
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