Kotak TATA

Kotak TATA (bahasa Inggris: TATA box, Goldberg-Hogness box) adalah deret DNA yang ditemukan pada area promoter inti dari gen eukariota. Kotak TATA merupakan elemen cis yang mengarahkan RNA polimerase II menuju ke area transkripsi dengan akurat.[1]

Hanya sekitar 10% dari gen manusia memiliki kotak TATA,[2] dan lebih dari 80% protein pada mamalia dihasilkan dari transkripsi gen yang tidak memiliki kotak TATA.[3]

Rujukan

  1. ^ (Inggris) "The RNA polymerase II core promoter". Howard Hughes Medical Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California; Smale ST, Kadonaga JT. Diakses tanggal 2010-08-23.
  2. ^ (Inggris) "Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters". Genetics Genomics and Bioinformatics Graduate Program, University of California; Yang C, Bolotin E, Jiang T, Sladek FM, Martinez E. Diakses tanggal 2010-08-23.
  3. ^ (Inggris) "Characterization of transcription from TATA-less promoters: identification of a new core promoter element XCPE2 and analysis of factor requirements". epartment of Biochemistry and Molecular Biology, Genes and Development Program of the Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center; Anish R, Hossain MB, Jacobson RH, Takada S. Diakses tanggal 2010-08-23.

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