Histidin

Histidin
Generelt
Systematisk navn 2-amino-3-(3H-imidazol-4-yl)propansyre
Andre navne Imidazolalanin
Molekylformel C6H9N3O2
Molmasse 155,16 g/mol
Hvis ikke andet er angivet, er data givet for
stoffer i standardtilstanden (ved 25 °C, 100 kPa)

Histidin (forkortet His og H) er en af de 20 standardaminosyrer i proteiner. I ernæring betragtes histidin som en af de essentielle aminosyrer. Den kodes for med CAU eller CAC.

Histidin blev første gang isoleret af tyskeren Albrecht Kossel i 1896.

Kemiske egenskaber

Imidazolsidekæden og den relativt neutrale pKa på 6,0 betyder at små ændringer i pH omkring fysiologisk pH resulterer i ændringer af histidins ladning, da denne ved svagt sure (og herunder) betingelser protoneres. Dette gør den anvendelig i active sites i enzymer, hvor den uden de store ændringer kan modtage og fraspalte en proton.

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