Johan Kriek defeated Steve Denton in the final, 6–2, 7–6(7–1), 6–7(1–7), 6–4 to win the men's singles tennis title at the 1981 Australian Open. It was his first major title.
Brian Teacher was the reigning champion, but did not compete this year.
Seeds
The seeded players are listed below. Johan Kriek is the champion; others show the round in which they were eliminated.