5,6-Dimethylbenzimidazole

5,6-Dimethylbenzimidazole
Names
	Preferred IUPAC name 5,6-Dimethyl-1H-benzimidazole
Identifiers
CAS Number	582-60-5 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	116595
ChEBI	CHEBI:15890;
ChEMBL	ChEMBL351132;
ChemSpider	655;
DrugBank	DB02591;
ECHA InfoCard	100.008.627
EC Number	209-488-1;
Gmelin Reference	279255
KEGG	C03114;
PubChem CID	675;
UNII	553XI1DS20;
CompTox Dashboard (EPA)	DTXSID70870631 ;
	InChI InChI=1S/C9H10N2/c1-6-3-8-9(4-7(6)2)11-5-10-8/h3-5H,1-2H3,(H,10,11) Key: LJUQGASMPRMWIW-UHFFFAOYSA-N; InChI=1/C9H10N2/c1-6-3-8-9(4-7(6)2)11-5-10-8/h3-5H,1-2H3,(H,10,11) Key: LJUQGASMPRMWIW-UHFFFAOYAV;
	SMILES CC1=CC2=C(C=C1C)N=CN2;
Properties
Chemical formula	C9H10N2
Molar mass	146.193 g·mol−1
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H302, H315, H319, H335, H412
Precautionary statements	P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

5,6-Dimethylbenzimidazole is a natural benzimidazole derivative. It is a component of vitamin B₁₂ where it serves as a ligand for the cobalt atom.^[1]

5,6-Dimethylbenzimidazole is biosynthesized from flavin mononucleotide by the enzyme 5,6-dimethylbenzimidazole synthase.^[2]

Chemical Structure

The IUPAC name for 5,6-Dimethylbenzimidazole is 1H-Benzimidazole, 5,6-dimethyl-. It consists of a benzene ring fused to an imidazole ring, with methyl groups positioned at specific carbon atoms.

Physical Properties

5,6-Dimethylbenzimidazole typically presents itself as a white to off-white crystalline solid. The compound has a molecular weight of approximately 146.19 g/mol, and its melting point falls within a specific temperature range.

Chemical Properties

The compound's chemical reactivity is attributed to the benzene and imidazole rings, enabling it to participate in various chemical reactions such as nucleophilic and electrophilic substitutions.

Occurrence and Uses

Biological Significance

Benzimidazole derivatives, including 5,6-Dimethylbenzimidazole, are known to occur in natural products and pharmaceuticals. They often exhibit diverse biological activities, making them intriguing subjects for further study.

Medicinal Chemistry

Researchers have explored the pharmacological properties of benzimidazole derivatives, with some displaying antimicrobial, antiviral, anticancer, and antifungal activities. The specific medicinal properties of 5,6-Dimethylbenzimidazole may vary based on its structural features and substituent.

Research Applications

In scientific research, 5,6-Dimethylbenzimidazole may find applications due to its unique structural characteristics. Additionally, it could serve as a valuable precursor in the synthesis of other compounds with specific desired properties.

References

^ Barker, HA; Smyth, RD; Weissbach, H; Toohey, JI; Ladd, JN; Volcani, BE (1960). "Isolation and properties of crystalline cobamide coenzymes containing benzimidazole or 5, 6-dimethylbenzimidazole". The Journal of Biological Chemistry. 235 (2): 480–8. doi:10.1016/S0021-9258(18)69550-X. PMID 13796809.
^ "5,6-Dimethylbenzimidazole biosynthesis". MetaCyc.

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[1] Barker, HA; Smyth, RD; Weissbach, H; Toohey, JI; Ladd, JN; Volcani, BE (1960). "Isolation and properties of crystalline cobamide coenzymes containing benzimidazole or 5, 6-dimethylbenzimidazole". The Journal of Biological Chemistry. 235 (2): 480–8. doi:10.1016/S0021-9258(18)69550-X. PMID 13796809.

[2] "5,6-Dimethylbenzimidazole biosynthesis". MetaCyc.

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