Pontisola was founded in 1910 in Ponte San Pietro as Società Sportiva Vita Nota and changed its denomination to Unione Sportiva Ponte San Pietro in 1950. The side spent the 1947–48 season in Serie B.
In 2007 the club, after the merger with F.C. Isola (representing the nearby towns of Terno d'Isola and Chignolo d'Isola), was renamed Unione Sportiva Ponte San Pietro Isola and later to the current one.