ADCK5

ADCK5
Identifiers
AliasesADCK5, aarF domain containing kinase 5
External IDsMGI: 2679274; GeneCards: ADCK5
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

203054

268822

Ensembl

ENSG00000173137
ENSG00000285451

ENSMUSG00000022550

UniProt

Q3MIX3

Q80V03

RefSeq (mRNA)

NM_174922

NM_172960

RefSeq (protein)

NP_777582

NP_766548

Location (UCSC)Chr 8: 144.37 – 144.39 MbChr 15: 76.46 – 76.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADCK5 (aarF domain containing kinase 5) is an enzyme that in humans is encoded by the ADCK5 gene. It is situated on chromosome 8 at the q24.3 location.

Function

ADCK5 is predicted to possess protein serine/threonine kinase activity and to be an integral component of the membrane.[5]

Genomic context

The ADCK5 gene is located on chromosome 8q24.3. The genomic sequence spans 20,154 base pairs from 144,373,088 to 144,393,242 on the GRCh38.p14 primary assembly. It consists of 19 exons.[5]

Expression

ADCK5 is ubiquitously expressed across various human tissues, with notable expression in the duodenum and small intestine, among others.[5]

Clinical significance

Research indicates that ADCK5 may have therapeutic implications in lung cancer.[6]

References

  1. ^ a b c ENSG00000285451 GRCh38: Ensembl release 89: ENSG00000173137, ENSG00000285451 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022550 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "ADCK5 aarF domain containing kinase 5 [Homo sapiens (Human)] - Gene - NCBI".
  6. ^ Qiu, M; Li, G; Wang, P; Li, X; Lai, F; Luo, R; Liu, B; Lin, J (1 July 2020). "aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway". Experimental Cell Research. 392 (1) 112002. doi:10.1016/j.yexcr.2020.112002. PMID 32277958.

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