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APLP1
Identifiers
Aliases	APLP1, APLP, amyloid beta precursor like protein 1
External IDs	OMIM: 104775; MGI: 88046; GeneCards: APLP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PMR, 3Q7G, 3Q7L, 3QMK, 4RD9, 4RDA
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,879,792 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,144,960 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; inferior olivary nucleus; ; middle frontal gyrus; ; right frontal lobe; ; prefrontal cortex; ; caudate nucleus; ; nucleus accumbens; ; dorsal motor nucleus of vagus nerve; ; amygdala; ; hypothalamus;
	Top expressed in
	nucleus accumbens; ; nucleus of stria terminalis; ; piriform cortex; ; molar; ; subiculum; ; olfactory tubercle; ; central gray substance of midbrain; ; globus pallidus; ; primary visual cortex; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	alpha-2C adrenergic receptor binding; heparin binding; alpha-2B adrenergic receptor binding; metal ion binding; protein binding; alpha-2A adrenergic receptor binding; identical protein binding; transition metal ion binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; basement membrane; perinuclear region of cytoplasm;
Biological process	endocytosis; nervous system development; cellular response to norepinephrine stimulus; cell adhesion; animal organ morphogenesis; apoptotic process; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	333
	11803
	ENSG00000105290
	ENSMUSG00000006651
	P51693
	Q03157
	NM_005166; NM_001024807
	NM_007467
	NP_001019978; NP_005157
	NP_031493
	Wikidata
View/Edit Human	View/Edit Mouse

Amyloid precursor like protein 1, also known as APLP1, is a protein encoded by the APLP1 gene in humans.^[5]^[6] APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.^[7]

Function

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.^[7]

APLP1 has also been implicated in the transmission pathologic α-synuclein in Parkinson's disease^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105290 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006651 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: APLP1 amyloid beta (A4) precursor-like protein 1".
^ Wasco W, Brook JD, Tanzi RE (January 1993). "The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19". Genomics. 15 (1): 237–9. doi:10.1006/geno.1993.1047. PMID 8432545.
^ ^a ^b Needham BE, Wlodek ME, Ciccotosto GD, Fam BC, Masters CL, Proietto J, et al. (June 2008). "Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth". J. Pathol. 215 (2): 155–63. doi:10.1002/path.2343. PMID 18393365. S2CID 1064378.
^ Mao X, Gu H, Kim D, Kimura Y, Wang N, Xu E, et al. (May 2024). "Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein". Nature Communications. 15 (1) 4663. Bibcode:2024NatCo..15.4663M. doi:10.1038/s41467-024-49016-3. PMC 11143359. PMID 38821932.
^ "New Study Suggests Cancer Drug Could Be Used to Target Protein Connection That Spurs Parkinson's Disease". Johns Hopkins Medicine. 17 June 2024.

Bayer TA, Cappai R, Masters CL, Beyreuther K, Multhaup G (November 1999). "It all sticks together--the APP-related family of proteins and Alzheimer's disease". Molecular Psychiatry. 4 (6): 524–528. doi:10.1038/sj.mp.4000552. PMID 10578233.
Kim TW, Wu K, Xu JL, McAuliffe G, Tanzi RE, Wasco W, et al. (August 1995). "Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density". Brain Research. Molecular Brain Research. 32 (1): 36–44. doi:10.1016/0169-328X(95)00328-P. PMID 7494461.
Bush AI, Pettingell WH, de Paradis M, Tanzi RE, Wasco W (October 1994). "The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily". The Journal of Biological Chemistry. 269 (43): 26618–26621. doi:10.1016/S0021-9258(18)47062-7. PMID 7929392.
Wasco W, Brook JD, Tanzi RE (January 1993). "The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19". Genomics. 15 (1): 237–239. doi:10.1006/geno.1993.1047. PMID 8432545.
Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, et al. (October 1996). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein". Human Molecular Genetics. 5 (10): 1589–1598. doi:10.1093/hmg/5.10.1589. PMID 8894693.
Paliga K, Peraus G, Kreger S, Dürrwang U, Hesse L, Multhaup G, et al. (December 1997). "Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid". European Journal of Biochemistry. 250 (2): 354–363. doi:10.1111/j.1432-1033.1997.0354a.x. PMID 9428684.
Lenkkeri U, Kestilä M, Lamerdin J, McCready P, Adamson A, Olsen A, et al. (February 1998). "Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1". Human Genetics. 102 (2): 192–196. doi:10.1007/s004390050676. PMID 9521588. S2CID 709094.
McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT (August 1998). "Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains". Brain Research. 804 (1): 45–51. doi:10.1016/S0006-8993(98)00653-2. PMID 9729270. S2CID 25127562.
Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, et al. (January 1999). "Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein". The Journal of Biological Chemistry. 274 (4): 2243–2254. doi:10.1074/jbc.274.4.2243. PMID 9890987.
Homayouni R, Rice DS, Sheldon M, Curran T (September 1999). "Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1". The Journal of Neuroscience. 19 (17): 7507–7515. doi:10.1523/JNEUROSCI.19-17-07507.1999. PMC 6782519. PMID 10460257.
Simons A, Ruppert T, Schmidt C, Schlicksupp A, Pipkorn R, Reed J, et al. (July 2002). "Evidence for a copper-binding superfamily of the amyloid precursor protein". Biochemistry. 41 (30): 9310–9320. doi:10.1021/bi0258647. PMID 12135352.
Scheinfeld MH, Ghersi E, Laky K, et al. (2003). "Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription". J. Biol. Chem. 277 (46): 44195–201. doi:10.1074/jbc.M208110200. PMID 12228233.
Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, et al. (June 2003). "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins". Biochemistry. 42 (22): 6664–6673. doi:10.1021/bi027375c. PMID 12779321.
Yamakami M, Yoshimori T, Yokosawa H (December 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". The Journal of Biological Chemistry. 278 (52): 52865–52872. doi:10.1074/jbc.M306740200. PMID 14563850.
Adlerz L, Beckman M, Holback S, Tehranian R, Cortés Toro V, Iverfeldt K (November 2003). "Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction". Brain Research. Molecular Brain Research. 119 (1): 62–72. doi:10.1016/j.molbrainres.2003.08.014. PMID 14597230.
Li Q, Südhof TC (March 2004). "Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1". The Journal of Biological Chemistry. 279 (11): 10542–10550. doi:10.1074/jbc.M310001200. PMID 14699153.
Eggert S, Paliga K, Soba P, Evin G, Masters CL, Weidemann A, et al. (April 2004). "The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation". The Journal of Biological Chemistry. 279 (18): 18146–18156. doi:10.1074/jbc.M311601200. PMID 14970212.

External links

Human APLP1 genome location and APLP1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105290 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006651 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: APLP1 amyloid beta (A4) precursor-like protein 1".

[pmid8432545-6] Wasco W, Brook JD, Tanzi RE (January 1993). "The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19". Genomics. 15 (1): 237–9. doi:10.1006/geno.1993.1047. PMID 8432545.

[pmid18393365-7] Needham BE, Wlodek ME, Ciccotosto GD, Fam BC, Masters CL, Proietto J, et al. (June 2008). "Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth". J. Pathol. 215 (2): 155–63. doi:10.1002/path.2343. PMID 18393365. S2CID 1064378.

[8] Mao X, Gu H, Kim D, Kimura Y, Wang N, Xu E, et al. (May 2024). "Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein". Nature Communications. 15 (1) 4663. Bibcode:2024NatCo..15.4663M. doi:10.1038/s41467-024-49016-3. PMC 11143359. PMID 38821932.

[9] "New Study Suggests Cancer Drug Could Be Used to Target Protein Connection That Spurs Parkinson's Disease". Johns Hopkins Medicine. 17 June 2024.

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APLP1

Function

References

Further reading

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