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Gamma secretase is a multi-subunit protease complex, an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within...

Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic...

Secretases are enzymes that "snip" pieces off a longer protein that is embedded in the cell membrane. Among other roles in the cell, secretases act on...

Beta-secretase 2 (EC 3.4.23.45, also known as memapsin-1) is an enzyme that cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's...

Beta-secretase is a protein family that includes in humans Beta-secretase 1 and Beta-secretase 2. Tallon C, Farah MH (October 2017). "Beta secretase activity...

Nivegacetor is an investigational gamma-secretase modulator being developed by Roche for the treatment of Alzheimer's disease. The compound is also known...

processed by beta secretase and gamma secretase. The alpha-secretase pathway is the predominant APP processing pathway. Thus, alpha-secretase cleavage precludes...

Gamma-secretase-activating protein, also known as Protein pigeon homolog (PION) is a protein that in humans is encoded by the GSAP gene. The human PION...

astrocytes. Following cleavage by β-secretase, APP is cleaved by a membrane-bound protein complex called γ-secretase to generate Aβ. Presenilins 1 and 2...

the gamma secretase complex along with the catalytic subunit presenilin and the regulatory subunits nicastrin and PEN-2. The gamma-secretase complex is...

post-injury repair. In Alzheimer's disease, the enzymes gamma secretase and beta secretase act together in a proteolytic process that divides APP into smaller...

RO4929097 (RG-4733) is a gamma secretase inhibitor being studied as an anti-cancer drug. Targeting gamma secretase inhibits NOTCH signaling, which is...

transmembrane proteins which constitute the catalytic subunits of the gamma-secretase intramembrane protease protein complex. They were first identified in...

PSEN1 gene. Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in generation of...

medication used for the treatment of desmoid tumors. It is a selective gamma secretase inhibitor that is taken by mouth. Nirogacestat was approved for medical...

enhancer 2), is a protein that is a regulatory component of the gamma secretase complex, a protease complex responsible for proteolysis of transmembrane...

amyloid β- peptide (Aβ)17–40/42 is the peptide resulting from the α- and γ-secretase cleavage from the amyloid precursor protein (APP). It is known to be the...

amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol-dependent process and substrate...

fragments. It is commonly cleaved by proteases in the secretase family; alpha secretase and beta secretase both remove nearly the entire extracellular domain...

endosomes, cleaved by beta-secretase (BACE), after which it moves back to the cell surface to be cleaved by gamma secretase thus releasing the Aβ peptide...

member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations...

APP is cleaved into smaller fragments by enzymes such as gamma secretase and beta secretase. One of these fragments gives rise to fibrils of amyloid beta...

therapy. Other methods being studied include the use of antioxidants, gamma secretase inhibition, adrenergic agonists, and memantine. Research is often carried...

expression levels of Alzheimer's disease-related proteins include β-secretase, γ-secretase, and amyloid plaque also alter dendritic spine density. Closer proximity...

signaling pathway. DAPT is a γ-secretase inhibitor. It indirectly inhibits Notch, which is a substrate for γ-secretase. In a mouse model of Alzheimer's...

proteases: this group includes presenilin, the active subunit of gamma secretase and signal peptide peptidases (SPPs) and SPP-like proteases, which are...

enzymes: first, by beta secretase (or β-amyloid cleaving enzyme (BACE)) outside the membrane, and second, by gamma secretase (γ-secretase), an enzyme complex...

first by β-secretase and then γ-secretase to produce amyloid beta peptide. Most of the APP mutations cluster near the β-secretase and γ-secretase cleaving...

α- or β- secretase, followed by γ-secretase. β- and γ-secretases cleave APP into Aβ in the amyloidogenic pathway whereas α- and γ-secretase inhibit Aβ...

(APP) by beta-secretase (β-secretase) and gamma-secretase (γ-secretase) produces various forms of amyloid beta (Aβ) peptides. Most β-secretase activity originates...

cells. Several Notch signaling pathway inhibitors, including the gamma secretase inhibitor LY3056480, are being studied for their potential ability to...

2174/1871527313666141023145703. PMID 25345508. Menting KW, Claassen JA (2014). "β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease"...

Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor". Journal of Medicinal Chemistry. 55 (7): 3414–3424. doi:10...

included programs focused on small molecule inhibitors of beta-secretase and gamma secretase, enzymes whose actions are thought to affect the accumulation...

shedding events. In neurons, ADAM10 is the most important enzyme, with α-secretase activity for proteolytic processing of the amyloid precursor protein....

Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". The Journal of Biological...

MG132 also inhibits NF-κB activation with an IC50 of 3 μM and prevents β-secretase cleavage. There are several inhibitors that can readily enter cell and...

development of Alzheimer's. Semagacestat blocks the enzyme γ-secretase, which (along with β-secretase) is responsible for APP proteolysis. Phase III double-blind...

that the Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. The other main effect the discovery...

(15 February 2000). "Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein". Proceedings of the National Academy...

paper, a mutation in the PSEN1 gene was found, which alters the gamma-secretase function and is known as a possible cause of early-onset Alzheimer's disease...

treatment of neurodegenerative diseases and treatments. interest are the secretases, proteases which cleave the amyloid precursor protein (APP), resulting...

ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage". J. Biol. Chem. 278 (10): 7751–4. doi:10.1074/jbc.C200711200...

for the treatment of Alzheimer's disease. It is an inhibitor of beta-secretase 1 (BACE1), which, after initial promise proved disappointing. In April...

gene. Nicastrin (abbreviated NCT) is a protein that is part of the gamma secretase protein complex, which is one of the proteases involved in processing...

cleaved, the small remaining integral membrane fragment is digested by γ-secretase. This protein is involved in melanosome maturation, including melanogenesis...

in the FTL expression and PEN-2 levels, which results in increased γ- secretase activity. In relation to this, the downregulation of FTL expression leads...

β-peptides (Aβ), through mechanisms of the amyloid precursor protein secretase, γ-secretase, responsible for the development of plaques, observed in Alzheimer's...

cleavage of the β-amyloid precursor protein (βΑPP) through β- and γ- secretases. Like other pro-inflammatory mediators, Aβ42 induces inflammation through...

encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This...

AD pathology has been shown to be in part mediated by an increase in δ-secretase levels, via an upregulation of the JAK2/STAT3 pathway and C/EBPβ downstream...

Asparagine endopeptidase (AEP, mammalian legumain, δ-secretase; EC 3.4.22.34) is a proteolytic enzyme from C13 peptidase family which hydrolyses a peptide...

and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins". Biochemistry....

FY, Shah JJ, Bertino JR, Rosenfeld J, et al. (December 2017). "Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma"...

function by regulating mitochondrial γ-secretase activity under hypoxic conditions. In the absence of HIGD1A, γ-secretase contributes to the accumulation of...

Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase". Nature Medicine. 14 (7): 723–730. Bibcode:2008NatMe..14..723F. doi:10...

hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth...

Gielen O, Jacobs K, Provost S, et al. (June 2021). "PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively...

Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. Bibcode:2003PNAS..100...

Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase". Nat Med. 14 (7): 723–730. doi:10.1038/nm1784. PMC 2826895. PMID 18587408...

The closest (non-pathogenic) enzymatic equivalent in humans is the beta-secretase enzyme. Silva AM, Lee AY, Gulnik SV, Maier P, Collins J, Bhat TN, Collins...

postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins...

produce proteins that are all components of a complex called gamma- (γ-) secretase. This complex cuts apart (cleaves) many different proteins, which is a...

necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor". The Journal of Biological...

This is regulated by NG2, whose intracellular domain can be cleaved by γ-secretase and translocated to the nucleus. The NG2 ectodomain can also modulate...

PMID 25098767. Clinical trial number NCT01154452 for "Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With...

Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase". Nat Med. 14 (7): 723–730. doi:10.1038/nm1784. PMC 2826895. PMID 18587408...

(25 April 2008). "Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting". Science. 320 (5875): 520–523. Bibcode:2008Sci...

Lanabecestat (formerly known as AZD3293 or LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. A BACE inhibitor in theory would prevent...

is thought that this single nucleotide change affects the ability of γ-secretase to cleave the intracellular domain (ICD) of the Type 3 isoform of Neureglin...

The discovery that caprolactam-type gamma-secretase inhibitors target the SPP subunit of the gamma-secretase, which has been implicated in Alzheimer's...

strategies for anti-Alzheimer's treatments that suppress the beta secretase and gamma secretase enzymes that cleave APP to form Aβ, or modify the interactions...

091582298. PMC 33278. PMID 11331760. Gao Y, Pimplikar SW (2002). "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling...

peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor". J Biol Chem. 279 (15): 15153–60. doi:10.1074/jbc.M309305200...

caused by varying cleavages of APP by either beta secretase and gamma secretase or alpha secretase. The longer forms of APP are prone to aggregating and...

encoding enzyme beta-1,3-galactosyltransferase 5 BACE2: encoding enzyme beta-secretase 2 BACH1: encoding transcription factor transcription regulator protein...

S2CID 21977507. He X, Chang WP, Koelsch G, Tang J (Jul 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications...

PΔE. The membrane tethered PΔE fragment is further cleaved by the gamma secretase complex to yield a membrane-released fragment, PIC, that can translocate...

staging systems as they do not metastasize. Nirogacestat, a selective gamma secretase inhibitor, was approved for medical use in the United States in November...

LE, et al. (October 2021). "Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease". Neuropharmacology. 197 108737. doi:10...

LA, Carey BW, Pettingell WH, Kovacs DM (June 2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates...

(26 November 2008). "Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system". Neuron...

(3),(2011). 500-504. Gravenfors, Ylva, et al. "New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain." Journal...

Expression of PS1 is Sufficient to Elevate the Level and Activity of γ-Secretase in Vivo". PLOS ONE. 6 (11) e28179. Bibcode:2011PLoSO...628179L. doi:10...

colony-stimulating factor-1 receptor (CSF-1R) inhibitor [15] APH-1105 – α-secretase activator [16] Borneol/cilostazol (cilostazol dexborneol; cilostazol/borneol;...

antibody production. The membrane bound BCMA can be cleaved by gamma secretase, resulting in sBCMA, and released into the blood. Serum BCMA is found...

by buntanetap with an ED50 of 20mg/kg (median Effective Dose). The β-secretase activity in the mouse brain also could be reduced with elevated doses...

agreement with CoMentis from 2008 to 2014 focused on development of beta-secretase inhibitor therapeutics for Alzheimer's disease. In 2009, the company's...

"TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. Bibcode:2006Natur...

balloon-borne gamma-ray detector Nicastrin, a protein component of the gamma secretase enzyme complex Nocturnal clitoral tumescence, a spontaneous swelling of...

Steven Wagner began screening for a class of drugs that they termed "gamma secretase modulators (GSM)". GSM's reverse the Abeta42:Abeta40 ratio and thereby...

L, Condron MM, Haffner C, Friedmann E, et al. (August 2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease...

as other versions. Mutations in ABCA7 can lead to more activity of β-secretase, an enzyme that increases Aβ production. App mutations (mainly seen in...

γ-secretase activity and amyloid precursor protein (APP) localization along with the presenilin 1 (PS1), presenilin 2 (PS2) proteins. γ-secretase functions...

et al. (August 2003). "NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo". J. Clin. Invest. 112 (3): 440–9. doi:10.1172/JCI18162...

trial in 2025. It has also been tested with peptide inhibitors of beta-secretase 1 (BACE-1). Ruderisch, Nadine; Schlatter, Daniel; Kuglstatter, Andreas;...

enzymes secretases regulate the amyloid-beta accumulation. Recently, a link between cholinergic neuronal activity and the activity of alpha-secretase has...

currently at UTSW, in his group solved the structure of human Gamma secretase in a collaboration with Shi Yigong. Since 2016, Scheres has worked closely...

neurodegenerative diseases: insights on their acetylcholinesterase and beta-secretase inhibitory activities in vitro". The Journal of Venomous Animals and Toxins...

dystrophy and denervating diseases. Cathepsin B may function as a beta-secretase 1, cleaving amyloid precursor protein to produce amyloid beta. Overexpression...

S2CID 6021682. Roncarati R, Sestan N, Scheinfeld MH, et al. (2002). "The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb...

and gamma secretase to yield a 40-42 amino acid peptide responsible for amyloid plaques associated with Alzheimer's disease. The secretase enzymes are...

Chang Wan-Pin; Koelsch Gerald; Tang Jordan (July 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications...

secreted proteins by the actions of the plasma membrane protein gamma secretase. ApoE may be the signalling ligand responsible for ApoER2's role in modulating...

subunit gamma-1; see HBG1 Hemoglobin subunit gamma-2; see HBG2 Gamma secretase Laminin, gamma 1 Laminin, gamma 2 This disambiguation page lists articles...

ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma". Journal of Experimental & Clinical Cancer Research...

studies identified that a modified version of imatinib can bind to gamma-secretase activating protein (GSAP). GSAP selectively increases the production and...

proteolytic cleavage of the transmembrane protein through the actions of the γ-secretase complex catalytic subunit Presenilin. This was a significant interaction...

transforming growth factor beta 1, von Willebrand factor, pro-albumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, gonadotropin, and nerve growth...

LA, Carey BW, Pettingell WH, Kovacs DM (June 2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates...

(1999). "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity". Nature. 402 (6761): 533–7. Bibcode:1999Natur.402..533Y. doi:10...

S2CID 129089. Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease...

compared to controls, and the hyperactivity is blocked using a gamma-secretase inhibitor. These in vitro studies suggest that increasing Aβ concentrations...

Selkoe's group identified presenilin as the catalytic component of the γ-secretase complex, the enzyme responsible for processing APP into Aβ throughout...

metabolism Glucose signaling/cell death control Presenilin P. patens γ-secretase Cystoskeletal function Fungus Aconitase S. cerevisiae TCA cycle enzyme...

chemotherapy and (in T-ALL) may impact the effectiveness of therapeutic gamma-secretase inhibitors. Baraniskin and al. study show that miR-21, miR-19, and miR-92a...

cholesterol controls the clustering of amyloid precursor protein with gamma secretase in GM1 lipid domains. High cholesterol induces APP hydrolysis and the...

production of extracellular amyloid such as β-secretase and γ-secretase inhibitors. Currently the γ-secretase inhibitors are in phase II clinical trials...

of membrane proteins associated with presenilin expression and gamma-secretase function". FASEB J. 22 (3): 819–27. doi:10.1096/fj.07-9072com. PMID 17928364...

Furthermore, it was shown that Pcdhs are proteolytically processed by γ-secretase complex, which releases soluble intracellular fragments into the cytoplasm...

particular, the ratio of CSF neurogranin truncated at P75 to the beta-secretase BACE1 has been proposed as a potential marker of cognitive deterioration...

Cytoplasmic/C-terminal Domain, the smaller cleavage product of APP by gamma-secretase Australian Institute of Company Directors, an organisation supporting...

Sasagawa N, Ishiura S (2002). "A secreted form of human ADAM9 has an alpha-secretase activity for APP". Biochem. Biophys. Res. Commun. 293 (2): 800–5. Bibcode:2002BBRC...

DM, Smith TS. Identification of a novel aspartic protease (Asp 2) as β-secretase. Molecular and Cellular Neuroscience. 1999 Dec 1;14(6):419-27. According...

contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies". Journal of Computer-aided...

hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth...

PMID 7490080. Lee SF, Srinivasan B, Sephton CF, et al. (Aug 2011). "Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate...

Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity". Journal of Alzheimer's Disease. 26 (2): 387–408. doi:10.3233/JAD-2011-110101...

phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))"....

for stability and trafficking but not association of other presenilin/g-secretase components". J. Biol. Chem. 280 (17): 17020–17026. doi:10.1074/jbc.M409467200...

H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas...

S2CID 129089. Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease...

study, which features PBCAR269A in combination with nirogacestat, a gamma secretase inhibitor. In 2020, the FDA granted fast track designation to PBCAR269A...

of PTPmu to release the shed extracellular fragment, then by the gamma secretase complex in the transmembrane domain to release the PTPmu intracellular...

computer C99, a fragment of the amyloid precursor protein created by beta-secretase C99Shell, also known as C99, is a malicious web shell C99, a model of...

2019. De Strooper, B.; et al. (1999). "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain". Nature...

to activate a compensatory response involving activation of a- and g-secretases to produce more Aβ for neutralization of future free radicals (Tamagno...

NG, Inoue M, Hosia W, et al. (April 2012). "Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain". The...

Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase". primary. Nature Medicine. 14 (7): 723–30. Bibcode:2008NatMe..14..723F...

"Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing". Neurochemistry International...

dopaminergic cell replacement [181] Itanapraced (CHF-5074; CSP-1103) – γ-secretase modulator and non-steroidal anti-inflammatory drug (NSAID) derivative...

Impairment of retromer activity by VPS35 mutation also increases beta-secretase 1 (BACE1) activity, which cleaves larger APPs and enhances Aβ plaque toxicity...

stimulation of the M1 receptor activates AF267B, which in turn blocks β-secretase, which cleaves the amyloid precursor protein to produce the amyloid-beta...

PMID 9169836. Roncarati R, Sestan N, Scheinfeld MH, et al. (2002). "The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds...

Okamoto T (April 1998). "Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein". The Journal of...

apparatus. The amyloidogenic pathway leads to APP processing by γ-secretases and β-secretases such as BACE1, resulting in production of the neurotoxic amyloid...

therapies. Examples include use of BET inhibitors in combination with γ-secretase inhibitors for T-cell acute lymphoblastic leukemia and BRAF-inhibitor...

PMID 16381901. Stoeck A, Shang L, Dempsey PJ (July 2010). "Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated...

2023. It also has an additional "unknown" cell type characterized by β-secretase expression; this type is found in other Placozoans besides H1. Other relatively...

multiple myeloma, on its own and in conjunction with the selective gamma secretase inhibitor nirogacestat. GRCh38: Ensembl release 89: ENSG00000048462 –...

in gene regulation. For example, hypoxia-induced factor 1α mRNA and β-secretase mRNA are transcribed bidirectionally, and it has been shown that the antisense...

Beta-secretasePhospholipid:diacylglycerol acyltransferase Identifiers Symbol BACE Pfam PF02450 OPM superfamily 127 OPM protein 4x96 Membranome 271 Available...

in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors". Journal of Experimental Medicine. 204 (8): 1813–1824. doi:10...

is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells". Biochemical and Biophysical Research Communications. 352...

2016). "Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes". Chem. Sci. 1 (7): 3117–3122...

"TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production". Nature Communications. 6 (1) 8876. doi:10.1038/ncomms9876...

events. The third cleavage event in Notch synthesis is carried out by γ-secretase. This process requires the proton pump V-ATPase which is regulated by...

activity which liberates fatty acids from glycerolipids. PEDF enhances gamma-secretase activity, leading to the cleavage of the VEGF receptor 1 (VEGFR-1) transmembrane...

molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate?". Journal of Neurochemistry. 72 (3): 1215–23. doi:10.1046/j...

Journal of Experimental Medicine shows that blocking the enzyme beta-secretase (BACE1) in mice can substantially reduce the formation of plaques responsible...

Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor". J. Med. Chem. 55 (7): 3414–3424. doi:10.1021/jm300094u. PMID 22420884...

amyloid precursor protein (APP) by proteases referred to as the β and γ secretases. The physiological role of this processing is unclear, though it may play...

"Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin". Biochem. J. 391 (Pt 3): 513–25. doi:10...

PMID 15489334. Kim DY, Ingano LA, Carey BW, et al. (2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates...

is possibly a "prime candidate to host alien life". 9 January A gamma secretase inhibitor previously experimented for treating Alzheimer's disease is...

to interact with presenilin 1 (PS-1), the principal component of the γ-secretase complex responsible for the enzymatic cleavage of amyloid precursor protein...

Reinders J, Oefner P, Reichert TE, Bauer R (Nov 2013). "Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous...

S2CID 30699151. Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein...

(APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms...