Antigny-la-Ville is located some 60 km south-west of Dijon and 25 km north-west of Beaune. It can be accessed by the minor road D111 which runs off the D33 west of Bligny-sur-Ouche and passes west through the commune and the village continuing to join the D906 in the west. The D14 road also comes from Culètre in the north also passing through the village and continuing south to Lacanche. There are also many local roads giving access to the commune. In addition to the village there is also the hamlet of Chamoy in the north. The commune is mostly farmland but there are large forests in the west (the Bois du Petit Rondeau and the Bois de Retraite).[3]
The Ruisseau du Breuil forms part of the northern border of the commune and gathers some tributaries which rise in the commune flowing west through the Étang de Breuil to join the Arroux south of Viscolon.[3]