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C-type lectin
A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin.[3] The C-type designation is from their requirement for calcium for binding.[4] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.[5][6] ClassificationDrickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein.[7] This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).[8] Most recently, three further subgroups were added (XV to XVII).[3]
CLECs include:
The "NK Cell lectin-like receptors" are a very closely related group:[10]
Additional proteins containing this domain include:
References
External links
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Index:
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