CDS1

For the Cds1 tumor-suppressing kinase, see CHEK2.
CDS1
Identifiers
AliasesCDS1, CDS, CDP-diacylglycerol synthase 1, CDS 1
External IDsOMIM: 603548; MGI: 1921846; GeneCards: CDS1
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.7.7.41↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

1040

74596

Ensembl

ENSG00000163624

ENSMUSG00000029330

UniProt

Q92903

P98191

RefSeq (mRNA)

NM_001263

NM_173370

RefSeq (protein)

NP_001254

NP_775546

Location (UCSC)Chr 4: 84.58 – 84.65 MbChr 5: 101.91 – 101.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.[5][6][7]

Function

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.[8][9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163624 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029330 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (November 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID 9806839.
  6. ^ Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (March 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA and Cell Biology. 16 (3): 281–9. doi:10.1089/dna.1997.16.281. PMID 9115637.
  7. ^ a b "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".
  8. ^ Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–5. Bibcode:2005FEBSL.579.2161N. doi:10.1016/j.febslet.2005.03.007. PMID 15811335. S2CID 21937549.
  9. ^ Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.

Further reading

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