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Collagen, type XXVII, alpha 1

COL27A1
Identifiers
AliasesCOL27A1, STLS, collagen type XXVII alpha 1, collagen type XXVII alpha 1 chain
External IDsOMIM: 608461; MGI: 2672118; HomoloGene: 69400; GeneCards: COL27A1; OMA:COL27A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032161
NM_032888

NM_025685

RefSeq (protein)

NP_116277

NP_079961

Location (UCSC)Chr 9: 114.16 – 114.31 MbChr 4: 63.21 – 63.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene.[5]

COL27A1 is a type XXVII collagen. It was discovered by James Pace.[6] This gene appears to be turned on in cartilage, the eye, and in the ear. Type XXVII collagen is related to the "fibrillar" class of collagens and may play a role in development of the skeleton.

Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form major structural elements in extracellular matrices of cartilage, skin, and tendon.[5][7]

Location

COL27A1 is located on chromosome 9 in homo sapiens specifically on spot number 32.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196739Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045672Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: collagen".
  6. ^ Pace JM, Corrado M, Missero C, Byers PH (March 2003). "Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1". Matrix Biol. 22 (1): 3–14. doi:10.1016/S0945-053X(03)00007-6. PMID 12714037.
  7. ^ Boot-Handford RP, Tuckwell DS, Plumb DA, Rock CF, Poulsom R (August 2003). "A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family". J. Biol. Chem. 278 (33): 31067–77. doi:10.1074/jbc.M212889200. PMID 12766169.
  8. ^ "COL27A1 gene - Genetics Home Reference". ghr.nlm.nih.gov. Archived from the original on 2017-02-07.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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