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Cortisone acetate

Cortisone acetate
Clinical data
Trade namesAdreson, Cortison, Cortisone, Cortisone Acetate, Cortone, Cortistab, Cortisyl, others
Other namesCortisone 21-acetate; 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.006 Edit this at Wikidata
Chemical and physical data
FormulaC23H30O6
Molar mass402.487 g·mol−1
3D model (JSmol)
  • CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
  • InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
  • Key:ITRJWOMZKQRYTA-RFZYENFJSA-N

Cortisone acetate (brand names Adreson, Cortison, Cortisone, Cortisone Acetate, Cortone, Cortistab, Cortisyl, others) is a synthetic glucocorticoid corticosteroid and corticosteroid ester which is marketed (under prescription) in many countries throughout the world, including in the United States, the United Kingdom, and various other European countries.[1][2][3] It is the C21 acetate ester of cortisone,[1][2] and acts as a prodrug of cortisone in the body.[4]

References

  1. ^ a b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 317–. ISBN 978-1-4757-2085-3.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 276–. ISBN 978-3-88763-075-1.
  3. ^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 85–. ISBN 978-94-011-4439-1.
  4. ^ Løvås K, Husebye ES (December 2003). "Replacement therapy in Addison's disease". Expert Opinion on Pharmacotherapy. 4 (12): 2145–2149. doi:10.1517/14656566.4.12.2145. PMID 14640913. S2CID 37628998.
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