Cyclin D3

CCND3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3G33
Identifiers
Aliases	CCND3, cyclin D3
External IDs	OMIM: 123834; MGI: 88315; HomoloGene: 20419; GeneCards: CCND3; OMA:CCND3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	42,050,357 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	47,910,616 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; thymus; ; blood; ; spleen; ; lymph node; ; mononuclear cell; ; monocyte; ; right adrenal cortex; ; right lung; ; bone marrow;
	Top expressed in
	granulocyte; ; thymus; ; fetal liver hematopoietic progenitor cell; ; tibiofemoral joint; ; yolk sac; ; efferent ductule; ; human fetus; ; dermis; ; adrenal gland; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cyclin-dependent protein serine/threonine kinase activity; protein binding; protein kinase binding; protein kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity;
Cellular component	nucleoplasm; cyclin-dependent protein kinase holoenzyme complex; membrane; nucleus; cytoplasm;
Biological process	T cell proliferation; cell cycle; positive regulation of protein phosphorylation; signal transduction; positive regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of cell cycle; cell division; negative regulation of transcription by RNA polymerase II; regulation of cell population proliferation; regulation of insulin receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; mitotic cell cycle; protein phosphorylation; regulation of mitotic nuclear division; positive regulation of cell population proliferation; positive regulation of cell cycle; positive regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	896
	12445
	ENSG00000112576
	ENSMUSG00000034165
	P30281
	P30282
NM_001136017; NM_001136125; NM_001136126; NM_001287427; NM_001287434;
	NM_001760
	NM_001081635; NM_001081636; NM_007632
NP_001129489; NP_001129597; NP_001129598; NP_001274356; NP_001274363;
	NP_001751
	NP_001075104; NP_001075105; NP_031658
	Wikidata
View/Edit Human	View/Edit Mouse

G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.^[5]

Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G₁/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G₂ phase into mitosis after UV radiation.^[6]