Cyclin E2

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Structures	Swiss-model
Domains	InterPro

cyclin E2
cyclin E2
Identifiers
Symbol	CCNE2
NCBI gene	9134
HGNC	1590
OMIM	603775
RefSeq	NM_057749
UniProt	O96020
Other data
Locus	Chr. 8 q22.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).^[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.^[1]

References

^ ^a ^b Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S (January 1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.

Zariwala M, Liu J, Xiong Y (1998-11-26). "Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins". Oncogene. 17 (21): 2787–2798. doi:10.1038/sj.onc.1202505. ISSN 0950-9232. PMID 9840943. S2CID 7340570.

[pmid9858585-1] Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S (January 1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.

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