The Do 212 was an all-metal cantilevermonoplane with fixed wingtip floats and a 343 kW (460 hp) Hirth HM 512-B-0 12-cylinder air-cooled engine which, mounted aft of the cabin, was buried in the fuselage and drove a four-blade airscrew aft of the tail by means of a shaft which could be tilted upward 12° to provide water clearance.
Initial water taxiing trials resulted in the enlarging of the wingtip floats. On 3 August 1942, a few attempts to take off from water were made, but these failed. A Do 24 was used to tow the Do 212 and it finally flew; however, instability forced the pilot to ditch just after takeoff. Further trials ended the same way. Difficulties were also experienced with the extension shaft, and the cooling of the engine presented a problem. Consequently, no further testing was undertaken, and the prototype was scrapped in 1943.