EAF2

EAF2
Identifiers
Aliases	EAF2, BM040, TRAITS, U19, ELL associated factor 2
External IDs	OMIM: 607659; MGI: 2146616; HomoloGene: 10208; GeneCards: EAF2; OMA:EAF2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	121,886,526 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,695,365 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; monocyte; ; lymph node; ; trabecular bone; ; granulocyte; ; appendix; ; kidney tubule; ; epithelium of nasopharynx; ; rectum; ; spleen;
	Top expressed in
	female urethra; ; right kidney; ; proximal tubule; ; lacrimal gland; ; epithelium of urethra; ; epithelium of female urethra; ; seminal vesicula; ; pelvic part of vagina; ; male urethra; ; epithelium of male urethra;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein binding;
Cellular component	nuclear speck; transcription elongation factor complex; super elongation complex; nucleus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of cell growth; negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; apoptotic process; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	55840
	106389
	ENSG00000145088
	ENSMUSG00000022838
	Q96CJ1
	Q91ZD6
	NM_018456; NM_001320041
	NM_001113401; NM_001113405; NM_134111; NM_001358102
	NP_001306970; NP_060926
	NP_001106872; NP_001106876; NP_598872; NP_001345031
	Wikidata
View/Edit Human	View/Edit Mouse

ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene.^[5]^[6]^[7] It is part of the EAF family of proteins and plays a role in transcriptional elongation by interacting with ELL proteins.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145088 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022838 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ (Feb 2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–62. doi:10.1182/blood-2002-06-1664. PMID 12446457.
^ Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (Aug 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Res. 63 (15): 4698–704. PMID 12907652.
^ "Entrez Gene: EAF2 ELL associated factor 2".
^ Simone, Federico; Luo, Roger T.; Polak, Paul E.; Kaberlein, Joseph J.; Thirman, Michael J. (2003-03-15). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–2362. doi:10.1182/blood-2002-06-1664. ISSN 0006-4971.

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". J. Biochem. 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kong SE, Banks CA, Shilatifard A, et al. (2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10094–8. Bibcode:2005PNAS..10210094K. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
Xiao W, Jiang F, Wang Z (2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057. S2CID 32749490.
Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Lett. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145088 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12446457-5] Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ (Feb 2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–62. doi:10.1182/blood-2002-06-1664. PMID 12446457.

[pmid12907652-6] Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (Aug 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Res. 63 (15): 4698–704. PMID 12907652.

[entrez-7] "Entrez Gene: EAF2 ELL associated factor 2".

[8] Simone, Federico; Luo, Roger T.; Polak, Paul E.; Kaberlein, Joseph J.; Thirman, Michael J. (2003-03-15). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–2362. doi:10.1182/blood-2002-06-1664. ISSN 0006-4971.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

EAF2

References

Further reading

Information related to EAF2

Portal di Ensiklopedia Dunia