Edmund Pendleton (1721–1803) was a Virginia politician, lawyer and judge.

Edmund Pendleton may also refer to:

• Edmund H. Pendleton (1788–1862), U.S. Representative from New York, his great-nephew
• Edmund J. Pendleton (1899–1987), American organist, composer and conductor who lived much of his life in Paris, France

• Edmund Pendleton Gaines, U.S. general, another grandnephew of Edmund Pendleton (1721)

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