Protein-coding gene in the species Homo sapiens
Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene .[ 5] [ 6] [ 7]
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000070404 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020325 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R (Aug 1998). "FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders". Oncogene . 16 (22): 2949– 54. doi :10.1038/sj.onc.1201807 . PMID 9671416 . S2CID 10736135 . ^ Glusman G, Kaur A, Hood L, Rowen L (Nov 2004). "An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution" . BMC Evol Biol . 4 : 43. doi :10.1186/1471-2148-4-43 PMC 533870 PMID 15527507 . ^ a b "Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)" .
Further reading
Maguer-Satta V, Rimokh R (2005). "FLRG, member of the follistatin family, a new player in hematopoiesis". Mol. Cell. Endocrinol . 225 (1– 2): 109– 18. doi :10.1016/j.mce.2004.07.009 . PMID 15451575 . S2CID 25430198 . Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3491– 6. Bibcode :2000PNAS...97.3491D . doi :10.1073/pnas.97.7.3491 PMC 16267 PMID 10737800 . Tortoriello DV, Sidis Y, Holtzman DA, et al. (2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization" . Endocrinology . 142 (8): 3426– 34. doi :10.1210/endo.142.8.8319 PMID 11459787 . Bartholin L, Maguer-Satta V, Hayette S, et al. (2001). "FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins". Oncogene . 20 (39): 5409– 19. doi :10.1038/sj.onc.1204720 . PMID 11571638 . S2CID 29503172 . Bartholin L, Maguer-Satta V, Hayette S, et al. (2002). "Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function". Oncogene . 21 (14): 2227– 35. doi :10.1038/sj.onc.1205294 . PMID 11948405 . S2CID 1065429 . Hill JJ, Davies MV, Pearson AA, et al. (2002). "The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum" . J. Biol. Chem . 277 (43): 40735– 41. doi :10.1074/jbc.M206379200 PMID 12194980 . Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R (2003). "Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells". Mol. Hum. Reprod . 8 (11): 992– 7. doi :10.1093/molehr/8.11.992 . PMID 12397211 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Maguer-Satta V, Bartholin L, Jeanpierre S, et al. (2003). "Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family". Exp. Cell Res . 282 (2): 110– 20. doi :10.1016/S0014-4827(02)00013-7 . PMID 12531697 . Wang HQ, Takebayashi K, Tsuchida K, et al. (2003). "Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells" . J. Clin. Endocrinol. Metab . 88 (9): 4432– 9. doi :10.1210/jc.2002-021758 PMID 12970321 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265– 70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Xia Y, Sidis Y, Schneyer A (2004). "Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice" . Mol. Endocrinol . 18 (4): 979– 94. doi :10.1210/me.2003-0364 PMID 14739256 . Florio P, Ciarmela P, Toti P, et al. (2004). "Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide". Mol. Cell. Endocrinol . 218 (1– 2): 129– 35. doi :10.1016/j.mce.2003.12.019 . PMID 15130517 . S2CID 42635058 . Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819– 24. doi :10.1110/ps.04682504 . PMC 2286551 PMID 15340161 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Saito S, Sidis Y, Mukherjee A, et al. (2006). "Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3" . Endocrinology . 146 (12): 5052– 62. doi :10.1210/en.2005-0833 PMID 16150905 . Okamoto A, Endo H, Kalionis B, et al. (2006). "IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta". Placenta . 27 (2– 3): 317– 21. doi :10.1016/j.placenta.2004.12.007 . PMID 16338475 .
External links
Information related to FSTL3
