GPAT4
Glycerol-3-phosphate acyltransferase 4 is a glycerol-3-phosphate acyltransferase that in humans is encoded by the GPAT4 gene.[5]
Function
GPAT4 is involved in the biosynthesis of triglycerides.[6] The majority of triglycerides are synthesised from glycerol 3-phosphate (G3P) via the addition of three fatty acyl-CoA substrates, which are made from fatty acids. The first of these additions is catalysed by glycerol-3-phosphate acyltransferases (GPATs: EC 2.3.1.15), including GPAT4, yielding lysophosphatidic acid.[7] GPAT4 has been shown to be important for lactation, with quantitative trait locus (QTL) for several milk production and composition traits observed at this locus in cattle.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000158669 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031545 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Glycerol-3-phosphate acyltransferase 4". Retrieved 2018-10-10.
- ^ Coleman RA, Lee DP (March 2004). "Enzymes of triacylglycerol synthesis and their regulation". Progress in Lipid Research. 43 (2): 134–76. doi:10.1016/S0163-7827(03)00051-1. PMID 14654091.
- ^ Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G (April 2008). "AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase". Journal of Biological Chemistry. 283 (15): 10048–57. doi:10.1074/jbc.M708151200. PMC 2442282. PMID 18238778.
- ^ Littlejohn MD, Tiplady K, Lopdell T, Law TA, Scott A, Harland C, Sherlock R, Henty K, Obolonkin V, Lehnert K, Macgibbon A, Spelman RJ, Davis SR, Snell RG (January 2014). "Expression Variants of the Lipogenic AGPAT6 Gene Affect Diverse Milk Composition Phenotypes in Bos taurus". PLOS ONE. 9 (1) e85757. Bibcode:2014PLoSO...985757L. doi:10.1371/journal.pone.0085757. PMC 3897493. PMID 24465687.
Further reading
- Tan XJ, Huang ZP, Li LY, Nie DS, Zhong CG, Fu JJ, Lu GX (April 2006). "Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis". Yi Chuan Xue Bao. 33 (4): 294–303. doi:10.1016/S0379-4172(06)60054-1. PMID 16625827.
- Shan D, Li JL, Wu L, Li D, Hurov J, Tobin JF, Gimeno RE, Cao J (July 2010). "GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis". J. Lipid Res. 51 (7): 1971–81. doi:10.1194/jlr.M006304. PMC 2882735. PMID 20181984.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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