María Guadalupe Morales Rubio (born 11 March 1966) is a Mexican politician. At different times she has been associated with the National Regeneration Movement (Morena),^[1] the Party of the Democratic Revolution (PRD) and the National Action Party (PAN).^[2]

From 2000 to 2003 she was the mayor of the Federal District's borough of Venustiano Carranza.^[1]

In 2003–2006 she served as a federal deputy in the 59th Congress, representing the Federal District's ninth district for the PRD.^[3]

In 2018 she left the PRD for Morena and successfully ran for a seat in the Congress of Mexico City.^[4]

On 14 October 2024 she returned to the Chamber of Deputies as the alternate of Ifigenia Martínez, who was elected as a plurinominal deputy for Morena during the 66th Congress but died in office on 5 October.^[5][1]

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