Human protein-coding gene
H3C14 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IIJ , 2X4W , 2X4X , 2X4Y , 3AV1 , 3DB3 , 3MO8 , 3R93 , 4MZF , 4MZG , 4MZH , 4OUC , 5BO0 , 2HIO , 5B0Z , 2ARO , 1EQZ , 1HQ3 , 4KGC , 1TZY , 4UUZ , 2F8N , 5B0Y , 4LD9 , 5B40 , 5CIU
Identifiers Aliases H3C14 External IDs OMIM : 142780 ; MGI : 3650546 ; HomoloGene : 134475 ; GeneCards : H3C14 ; OMA :H3C14 - orthologs Wikidata
Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene .[ 4] [ 5] [ 6]
Function
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome , an octamer composed of pairs of each of the four core histones (H2A , H2B , H3 , and H4 ). The chromatin fiber is further compacted through the interaction of a linker histone, H1 , with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.[ 6]
Interactions
HIST2H3C has been shown to interact with NCOA6 .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000203811 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes" . Genomics . 80 (5): 487– 498. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 . ^ Marashi F, Helms S, Shiels A, Silverstein S, Greenspan DS, Stein G, Stein J (Jul 1986). "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences" . Biochem Cell Biol . 64 (4): 277– 289. doi :10.1139/o86-039 . PMID 3013246 . ^ a b "Entrez Gene: HIST2H3C histone cluster 2, H3c" .^ Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins" . Mol. Cell. Biol . 23 (1): 140– 149. doi :10.1128/MCB.23.1.140-149.2003 . PMC 140670 PMID 12482968 .
Further reading
Green L, Van Antwerpen R, Stein J, Stein G, Tripputi P, Emanuel B, Selden J, Croce C (1984). "A major human histone gene cluster on the long arm of chromosome 1". Science . 226 (4676): 838– 840. Bibcode :1984Sci...226..838G . doi :10.1126/science.6494913 . PMID 6494913 . Ohe Y, Iwai K (1982). "Human spleen histone H3. Isolation and amino acid sequence". J. Biochem . 90 (4): 1205– 11. doi :10.1093/oxfordjournals.jbchem.a133573 . PMID 7309716 . DÃaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M (1996). "Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay". Biochim. Biophys. Acta . 1296 (2): 219– 27. doi :10.1016/0167-4838(96)00072-6 . PMID 8814229 . Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet . 101 (3): 284– 294. doi :10.1007/s004390050630 . PMID 9439656 . S2CID 38539096 . El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter" . Mol. Cell. Biol . 18 (5): 2535– 44. doi :10.1128/mcb.18.5.2535 . PMC 110633 PMID 9566873 . Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3". Mamm. Genome . 10 (7): 768– 770. doi :10.1007/s003359901089 . PMID 10384058 . S2CID 28275496 . Goto H, Tomono Y, Ajiro K, Kosako H, Fujita M, Sakurai M, Okawa K, Iwamatsu A, Okigaki T, Takahashi T, Inagaki M (1999). "Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation" . J. Biol. Chem . 274 (36): 25543– 25549. doi :10.1074/jbc.274.36.25543 PMID 10464286 . Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones" . Virology . 277 (2): 278– 295. doi :10.1006/viro.2000.0593 PMID 11080476 . Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature . 410 (6824): 116– 120. doi :10.1038/35065132 . PMID 11242053 . S2CID 4331863 . Shankaranarayanan P, Chaitidis P, Kühn H, Nigam S (2001). "Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene" . J. Biol. Chem . 276 (46): 42753– 42760. doi :10.1074/jbc.M102626200 PMID 11509556 . Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA" . Virology . 289 (2): 312– 326. doi :10.1006/viro.2001.1129 PMID 11689053 . Goto H, Yasui Y, Nigg EA, Inagaki M (2002). "Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation". Genes Cells . 7 (1): 11– 17. doi :10.1046/j.1356-9597.2001.00498.x . PMID 11856369 . S2CID 23717416 . Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM (2002). "BRCA1 supports XIST RNA concentration on the inactive X chromosome" . Cell . 111 (3): 393– 405. doi :10.1016/S0092-8674(02)01052-8 PMID 12419249 . S2CID 372211 . Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins" . Mol. Cell. Biol . 23 (1): 140– 149. doi :10.1128/MCB.23.1.140-149.2003 . PMC 140670 PMID 12482968 . Preuss U, Landsberg G, Scheidtmann KH (2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase" . Nucleic Acids Res . 31 (3): 878– 885. doi :10.1093/nar/gkg176 . PMC 149197 PMID 12560483 . Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1" . EMBO J . 22 (6): 1336– 1346. doi :10.1093/emboj/cdg120 . PMC 151047 PMID 12628926 . Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter" . EMBO J . 22 (24): 6550– 6561. doi :10.1093/emboj/cdg631 . PMC 291826 PMID 14657027 .
External links
PDB gallery
1aoi : COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT
1eqz : X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
1f66 : 2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z
1hq3 : CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE
1kx3 : X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution
1kx4 : X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution
1kx5 : X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution
1m18 : LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1m19 : LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1m1a : LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1p34 : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3a : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3b : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3f : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3g : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3i : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3k : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3l : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3m : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3o : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3p : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1s32 : Molecular Recognition of the Nucleosomal 'Supergroove'
1tzy : Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution
1u35 : Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
1zbb : Structure of the 4_601_167 Tetranucleosome
1zla : X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core
2aro : Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione
2cv5 : Crystal structure of human nucleosome core particle
2f8n : 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes
2fj7 : Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element
2hio : HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN
2hue : Structure of the H3-H4 chaperone Asf1 bound to histones H3 and H4
2io5 : Crystal structure of the CIA- histone H3-H4 complex
2nzd : Nucleosome core particle containing 145 bp of DNA
Information related to HIST2H3C
