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Hans Clevers

Hans Clevers
Clevers in 2018
Born
Johannes Carolus Clevers[2]

(1957-03-27) 27 March 1957 (age 67)[3][4][5]
NationalityDutch
Alma materUtrecht University
Known forOrganoid generation and application
SpouseEefke Petersen[6]
Children2[3]
AwardsLouis-Jeantet Prize for Medicine
Breakthrough Prize in Life Sciences
Dr A. H. Heineken Prize for Medicine
Körber European Science Prize
Scientific career
FieldsMolecular genetics
Cell biology
InstitutionsRoche
Princess Máxima Center [nl]
University Medical Center Utrecht
Hubrecht Institute for Developmental Biology and Stem Cell Research
Utrecht University
Dana–Farber Cancer Institute
ThesisEarly events in lymphocyte activation (1985)
Doctoral advisorRudy Ballieux[1]

Johannes (Hans) Carolus Clevers (born 27 March 1957)[3][4] is a Dutch molecular geneticist, cell biologist and stem cell researcher. He became the Head of Pharma, Research and Early Development, and a member of the Corporate Executive Committee, of the Swiss healthcare company Roche in 2022.[7][8] Previously, he headed a research group at the Hubrecht Institute for Developmental Biology and Stem Cell Research[9] and at the Princess Máxima Center [nl];[10] he remained as an advisor and guest scientist or visiting researcher to both groups.[7] He is also a Professor in Molecular Genetics at Utrecht University.[8]

Early life and education

Hans Clevers was born in Eindhoven, the Netherlands in 1957.[5] He began studying biology at Utrecht University in 1975, but also started taking medicine in 1978,[7] in part due to his interest and in part because his friends and brothers were in the medical profession.[11] He spent 1 year in Nairobi, Kenya, and half a year at the National Institutes of Health in Bethesda, United States, for biology rotations.[11][12] He received a Doctoraal (equivalent to an MSc) in Biology in 1982 and an Artsexamen (equivalent to an MD) in 1984. Mostly because of his research background, Clevers was selected for a training position in paediatrics, and then went to pursue a PhD in 1985, under the supervision of Rudy Ballieux.[1][13][14] He obtained his PhD 1 year later.[7][11]

Career

After his PhD, Clevers went to the Dana–Farber Cancer Institute as a postdoctoral researcher at Cox Terhorst's group.[8][11][15][16] In 1989, he returned to the Netherlands, joining his alma mater, Utrecht University, as an assistant professor at the Department of Clinical Immunology.[8]

In 1991, Clevers became a professor and the chair of the Department of Immunology at Utrecht University.[8] He moved to the University Medical Center Utrecht in 2002 as a professor in molecular genetics, and started his lab at the Hubrecht Institute for Developmental Biology and Stem Cell Research (Hubrecht Institute).[7] At the same time, he took up the position of Director of the Hubrecht Institute.[8]

In March 2012, Clevers was elected the president of the Royal Netherlands Academy of Arts and Sciences, succeeding Robbert Dijkgraaf.[17][18] His term concluded in 2015, and he started another lab at the Princess Máxima Center [nl],[8] focusing on childhood cancer,[10] and became the Director Research and Chief Scientific Officer there until 2019.[8]

Clevers left University Medical Center Utrecht and was appointed Professor in Molecular Genetics at Utrecht University in 2020.[7]

In 2022, Clevers joined the Swiss healthcare company Roche as its Head of Pharma, Research and Early Development and a member of its Corporate Executive Committee.[19][20] He remains an advisor and guest scientist or visiting researcher to his research groups at the Princess Máxima Center and Hubrecht Institute.[9][10]

Since 2017, Clevers is an investigator at the Oncode Institute in Utrecht.[7][21]

Clevers has served at a number of scientific organizations, including on the board of directors of the American Association for Cancer Research (2013-2016),[22] and the Scientific Advisory Board of the Swiss Institute for Experimental Cancer Research at the École Polytechnique Fédérale de Lausanne (2005-2015),[8] the Research Institute of Molecular Pathology in Vienna (2015-2021)[23] and the Francis Crick Institute in London.[24] He is currently on the advisory board of various scientific journals, including The EMBO Journal,[25] Disease Models & Mechanisms,[26] Cell,[27] Cell Stem Cell[28] and EMBO Molecular Medicine.[29] From 2014 to 2022, he was also on the editorial committee of the Annual Review of Cancer Biology.[7]

Outside the academia, Clevers has been a scientific advisor to numerous biotechnology companies.[7] He also co-founded California-based Surrozen[30] in 2016[31] and Shanghai-based D1 Medical Technology[32] in 2019.[33]

Hans Clevers interviewed for the Dutch television show The Mind of the Universe

Research

Clevers's early career focused on the Wnt signaling pathway.[34] His group identified the TCF1 protein, a member of the TCF gene family and a crucial downstream component of the Wnt signaling pathway, making it central in immune responses, embryonic development and tissue repair.[35] His interest in the gastrointestinal tract began with the discovery that another TCF family member, the TCF4 protein, is required in forming intestinal crypts.[36] Collaborating with Bert Vogelstein, he found that in colon cancer where the APC gene is doubly mutated, TCF family members activate catenin beta-1, which then enhances the expression of many genes that cause cancer transformation,[37] connecting the Wnt signaling pathway with colon cancer.

In 2007, Clevers's group identified a marker for stem cells of the small and large intestines, LGR5, itself also a target of the Wnt signaling pathway.[38] This led to his finding that LGR5 is a stem cell marker in other organs as well, including the stomach[39] and hair follicles.[40]

Building on this discovery, in 2009, his group published a landmark paper, describing for the first time how organoids, which are 3-dimensional in vitro structures that behave anatomically and molecularly like the organ from which they are derived, were generated from adult stem cells, creating organoids of the small intestine.[41] Clevers's group has applied this technology to culturing organoids from other organs, such as the stomach[39] and liver,[42] as well as from various cancer types, including cancer of the breast[43] and the ovaries.[44] This platform has since been applied in personalized medicine, by generating organoids from specific patients to screen for drugs.[45][46] This is not limited to cancer but is applicable to other diseases as well (for example, cystic fibrosis).[47] His current major research interest is in using organoids derived from adult stem cells to study the molecular mechanism of tissue and cancer development.

During the COVID-19 pandemic, Clevers's group modelled the infection of SARS-CoV-2 using lung organoids.[48]

Honours and awards

References

  1. ^ a b "Mentoring the Next Generation: Hans Clevers". Cell Stem Cell. 23 (6): 784–786. 2018. doi:10.1016/j.stem.2018.11.004. S2CID 239579550.
  2. ^ a b "Johannes Carolus Clevers". American Academy of Arts and Sciences. Archived from the original on 27 June 2022.
  3. ^ a b c d "2016 – Johannes C. Clevers". Ilse & Helmut Wachter Foundation, Medical University of Innsbruck. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  4. ^ a b c "Prof.dr. J.C. Clevers" (in Dutch). Utrecht University. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  5. ^ a b "Prof. dr. J.C. (Hans) Clevers" (in Dutch). University Medical Center Utrecht. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  6. ^ Clevers, Hans (1 October 2021). "The development of organoids for cancer research: an ode to the scientific method". Cancer World. Archived from the original on 29 June 2022. Retrieved 29 June 2022.
  7. ^ a b c d e f g h i j "CURRICULUM VITAE" (PDF). Utrecht University. Archived from the original (PDF) on 23 June 2022. Retrieved 23 June 2022.
  8. ^ a b c d e f g h i "Prof. Dr. Hans Clevers". Roche. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  9. ^ a b "Clevers: Adult stem cell-based organoids". Utrecht University. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  10. ^ a b c "Clevers group". Princess Máxima Center [nl]. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  11. ^ a b c d Clevers, H. (2013). "A gutsy approach to stem cells and signalling: an interview with Hans Clevers". Disease Models & Mechanisms. 6 (5): 1053–1056. doi:10.1242/dmm.013367. PMC 3759325. PMID 24046385. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  12. ^ "Hans Clevers on Becoming a Scientist". Cold Spring Harbor Laboratory. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  13. ^ Menkhorst, Roos (22 June 2013). "Ik leerde het belang van vertrouwen in mezelf". Trouw (in Dutch). Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  14. ^ "Hans Clevers". Breakthrough Prize in Life Sciences. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
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  17. ^ van Aartsen, Carina (26 March 2012). "Hans Clevers volgt KNAW-president Robbert Dijkgraaf op". Zorgvisie (in Dutch). Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  18. ^ "President: Hans Clevers". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 1 February 2013.
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  20. ^ "Changes to the Roche Board of Directors and the Corporate Executive Committee" (Press release). Basel: Roche. 1 February 2022. Archived from the original on 23 June 2022. Retrieved 23 June 2022.
  21. ^ "Hans Clevers Group". Oncode Institute. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
  22. ^ "American Association for Cancer Research Councilors and Directors" (PDF). American Association for Cancer Research. Archived from the original (PDF) on 24 June 2022. Retrieved 24 June 2022.
  23. ^ "Former SAB Members". Research Institute of Molecular Pathology. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
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  25. ^ "Advisory Board Biographies". The EMBO Journal. Archived from the original on 27 June 2022. Retrieved 24 June 2022.
  26. ^ "Editors and Board". Disease Models & Mechanisms. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
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  32. ^ "创始团队" (in Chinese). D1 Medical Technology. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
  33. ^ "丹望医疗完成数千万元天使轮融资,凯风创投领投". Sina (in Chinese). 8 February 2021. Archived from the original on 24 June 2022. Retrieved 24 June 2022.
  34. ^ Sinha, Gunjan (2017). "The organoid architect". Science. 357 (6353): 746–749. doi:10.1126/science.357.6353.746. PMID 28839056. Archived from the original on 28 June 2022. Retrieved 28 June 2022.
  35. ^ van de Wetering, Marc; Oosterwegel, Mariette; Dooijes, Dennis; Clevers, Hans (1991). "Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box". The EMBO Journal. 10 (1): 123–132. doi:10.1002/j.1460-2075.1991.tb07928.x. PMC 452620. PMID 1989880.
  36. ^ Korinek, Vladimir; Barker, Nick; Moerer, Petra; van Donselaar, Elly; Huls, Gerwin; Peters, Peter J.; Clevers, Hans (1997). "Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4". Nature Genetics. 19 (4): 379–383. doi:10.1038/1270. PMID 9697701. S2CID 1052683. Retrieved 28 June 2022.
  37. ^ Korinek, Vladimir; Barker, Nick; Morin, Patrice J.; van Wichen, Dick; de Weger, Roel; Kinzler, Kenneth W.; Vogelstein, Bert; Clevers, Hans (1997). "Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma". Science. 275 (5307): 1784–1787. doi:10.1126/science.275.5307.1784. PMID 9065401. S2CID 33935423. Retrieved 28 June 2022.
  38. ^ Barker, Nick; van Es, Johan H.; Kuipers, Jeroen; Kujala, Pekka; van den Born, Maaike; Cozijnsen, Miranda; Haegebarth, Andrea; Korving, Jeroen; Begthel, Harry; Peters, Peter J.; Clevers, Hans (2007). "Identification of stem cells in small intestine and colon by marker gene Lgr5". Nature. 449 (7165): 1003–1007. Bibcode:2007Natur.449.1003B. doi:10.1038/nature06196. PMID 17934449. S2CID 4349637. Retrieved 23 June 2022.
  39. ^ a b Barker, Nick; Huch, Meritxell; Kujala, Pekka; van de Wetering, Marc; Snippert, Hugo J.; van Es, Johan H.; Sato, Toshiro; Stange, Daniel E.; Begthel, Harry; van den Born, Maaike; Danenberg, Esther; van den Brink, Stieneke; Korving, Jeroen; Abo, Arie; Peters, Peter J.; Wright, Nick; Poulsom, Richard; Clevers, Hans (2010). "Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro". Cell Stem Cell. 6 (1): 25–36. doi:10.1016/j.stem.2009.11.013. PMID 20085740.
  40. ^ Jaks, Viljar; Barker, Nick; Kasper, Maria; van Es, Johan H; Snippert, Hugo J; Clevers, Hans; Toftgård, Rune (2008). "Lgr5 marks cycling, yet long-lived, hair follicle stem cells". Nature Genetics. 40 (11): 1291–1299. doi:10.1038/ng.239. PMID 18849992. S2CID 10883817. Retrieved 23 June 2022.
  41. ^ Sato, Toshiro; Vries, Robert G.; Snippert, Hugo J.; van de Wetering, Marc; Barker, Nick; Stange, Daniel E.; van Es, Johan H.; Abo, Arie; Kujala, Pekka; Peters, Peter J.; Clevers, Hans (2009). "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche". Nature. 459 (7244): 262–265. Bibcode:2009Natur.459..262S. doi:10.1038/nature07935. PMID 19329995. S2CID 4373784. Retrieved 23 June 2022.
  42. ^ Huch, Meritxell; Dorrell, Craig; Boj, Sylvia F.; van Es, Johan H.; van de Wetering, Marc; Li, Vivian S.W.; Hamer, Karien; Sasaki, Nobuo; Finegold, Milton J.; Haft, Annelise; Grompe, Markus; Clevers, Hans (2013). "In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration". Nature. 494 (7436): 247–250. Bibcode:2013Natur.494..247H. doi:10.1038/nature11826. PMC 3634804. PMID 23354049.
  43. ^ Sachs, Norman; de Ligt, Joep; Kopper, Oded; Gogola, Ewa; Bounova, Gergana; Weeber, Fleur; Vanita Balgobind, Anjali; Wind, Karin; Gracanin, Ana; Begthel, Harry; Korving, Jeroen; van Boxtel, Ruben; Alves Duarte, Alexandra; Lelieveld, Daphne; van Hoeck, Arne; Ernst, Robert Frans; Blokzijl, Francis; Nijman, Isaac Johannes; Hoogstraat, Marlous; van de Ven, Marieke; Egan, David Anthony; Zinzalla, Vittoria; Moll, Jurgen; Fernandez Boj, Sylvia; Voest, Emile Eugene; Wessels, Lodewyk; van Diest, Paul Joannes; Rottenberg, Sven; Vries, Robert Gerhardus Jacob; Cuppen, Edwin; Clevers, Hans (2018). "A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity". Cell. 172 (1–2): 373–386. doi:10.1016/j.cell.2017.11.010. PMID 29224780. S2CID 8951522.
  44. ^ Kopper, Oded; de Witte, Chris J.; Lõhmussaar, Kadi; Valle-Inclan, Jose Espejo; Hami, Nizar; Kester, Lennart; Vanita Balgobind, Anjali; Korving, Jeroen; Proost, Natalie; Begthel, Harry; van Wijk, Lise M; Aristín Revilla, Sonia; Theeuwsen, Rebecca; van de Ven, Marieke; van Roosmalen, Markus J; Ponsioen, Bas; Ho, Victor W. H.; Neel, Benjamin G.; Bosse, Tjalling; Gaarenstroom, Katja N.; Vrieling, Harry; Vreeswijk, Maaike P. G.; van Diest, Paul J.; Witteveen, Petronella O.; Jonges, Trudy; Bos, Johannes L.; van Oudenaarden, Alexander; Zweemer, Ronald P.; Snippert, Hugo J. G.; Kloosterman 14, Hans Clevers, Wigard P. (2019). "An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity". Nature Medicine. 25 (5): 838–849. doi:10.1038/s41591-019-0422-6. PMID 31011202. S2CID 126428230. Retrieved 29 June 2022.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  45. ^ Bartfeld, Sina (2021). "Realizing the potential of organoids—an interview with Hans Clevers". Journal of Molecular Medicine. 99 (4): 443–447. doi:10.1007/s00109-020-02025-3. PMC 8026466. PMID 33464358.
  46. ^ Bender, Eric (2015). "Q&A: Hans Clevers". Nature. 521 (7551): S15. Bibcode:2015Natur.521S..15B. doi:10.1038/521S15a. PMID 25970453. S2CID 4452738.
  47. ^ Saini, Angela (2016). "Cystic Fibrosis Patients Benefit from Mini Guts" (PDF). Cell Stem Cell. 19 (4): 425–427. doi:10.1016/j.stem.2016.09.001. Archived from the original (PDF) on 25 June 2022. Retrieved 26 June 2022.
  48. ^ Lamers, Mart M; van der Vaart, Jelte; Knoops, Kèvin; Riesebosch, Samra; Breugem, Tim I; Mykytyn, Anna Z; Beumer, Joep; Schipper, Debby; Bezstarosti, Karel; Koopman, Charlotte D; Groen, Nathalie; Ravelli, Raimond B G; Duimel, Hans Q; Demmers, Jeroen A A; Verjans, Georges M G M; Koopmans, Marion P G; Muraro, Mauro J; Peters, Peter J; Clevers, Hans; Haagmans, Bart L (2021). "An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells". The EMBO Journal. 40 (5): e105912. doi:10.15252/embj.2020105912. PMC 7883112. PMID 33283287.
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Disambiguazione – Se stai cercando il film del 1986, vedi Sogno americano (film). Questa voce o sezione sull'argomento Stati Uniti d'America non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. Segui i suggerimenti del progetto di riferimento. Bandiere storiche degli Stati Uniti d'America esposte al Campidoglio di Washington. Per sogno americano (in inglese Ame…

Grottagliecomune Grottaglie – VedutaCastello Episcopio e Quartiere delle Ceramiche LocalizzazioneStato Italia Regione Puglia Provincia Taranto AmministrazioneSindacoCiro D'Alò (Sud in Movimento - liste civiche) dal 5-10-2021 TerritorioCoordinate40°32′N 17°26′E / 40.533333°N 17.433333°E40.533333; 17.433333 (Grottaglie)Coordinate: 40°32′N 17°26′E / 40.533333°N 17.433333°E40.533333; 17.433333 (Grottaglie) Altitudine13…

Синелобый амазон Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:ВторичноротыеТип:ХордовыеПодтип:ПозвоночныеИнфратип:ЧелюстноротыеНадкласс:ЧетвероногиеКлада:АмниотыКлада:ЗавропсидыКласс:Птиц…

До смерти красиваангл. Drop Dead Diva Жанры Комедия-драмаФэнтезиМюзикл Создатель Джош Берман Режиссёры Дэвид Петрарка[1]Майкл Гроссман[d][1]Роберт Дж. Уилсон[d][1]Джейми Бэббит[d][1] Сценаристы Джош Берман[d][1]Джеффри Липпман[d][1] В главных ролях Брук Эллиот…

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Ogden Air Logistics Complex – news · newspapers · books · scholar · JSTOR (March 2018) (Learn how and when to remove this template message) Ogden Air Logistics ComplexComplex badgeActive1943 (1943)–presentCountry United StatesBranch United States …

Aliran sungai Elbe di Eropa Elbe atau kadang kala Elba (Ceko Labe dengarkanⓘ, Sorbia/Lusatia Łobjo, Polandia Łaba, Jerman Elbe) ialah salah satu sungai utama di Eropa tengah. Berhulu di Republik Ceko Barat Laut. Kemudian mengalir melalui sebagian besar Jerman dan akhirnya bermuara di Laut Utara. Pengawasan otoritas Umum Integrated Authority File (Jerman) VIAF 1 WorldCat Perpustakaan nasional Amerika Serikat Republik Ceko

Nazi concentration camp in present-day Sztutowo, Poland Stutthof redirects here. Not to be confused with Struthof or Stuthof. StutthofNazi concentration campPrisoner barracks after liberationLocation of the former Stutthof concentration camp in PolandCoordinates54°19′44″N 19°09′14″E / 54.32889°N 19.15389°E / 54.32889; 19.15389LocationSztutowoOperated byGerman governmentCommandantMax Pauly, September 1939 – August 1942Paul-Werner Hoppe, August 1942 – Januar…

Peter WellerPeter Weller pada September 2011Lahir24 Desember 1948 (umur 75)Stevens Point, Wisconsin, A.S.PekerjaanAktor, sutradara, dosenTahun aktif1975–sekarangSuami/istriSheri Stowe ​(m. 2006)​ Peter Weller (lahir 24 Desember 1948) adalah aktor film dan panggung, sutradara, dan dosen sejarah asal Amerika Serikat. Ia dikenal karena menjadi pemeran RoboCop di dua film RoboCop pertama, Buckaroo Banzai di film klasik kultus The Adventures of Buckaroo Banzai…

Dutch physicist, Holocaust survivor and political activist (1924–2014) Hajo MeyerBornHans Joachim Gustav Meyer(1924-08-12)12 August 1924Bielefeld, North Rhine-Westphalia, GermanyDied23 August 2014(2014-08-23) (aged 90)Heiloo, The NetherlandsNationalityGerman-DutchScientific careerFieldsTheoretical physicist Short movie My good fortune in Auschwitz Hajo Meyer (born Hans Joachim Gustav Meyer; 12 August 1924 – 23 August 2014) was a German-born Dutch physicist, Holocaust survivor and politi…

この項目には、一部のコンピュータや閲覧ソフトで表示できない文字が含まれています(詳細)。 数字の大字(だいじ)は、漢数字の一種。通常用いる単純な字形の漢数字(小字)の代わりに同じ音の別の漢字を用いるものである。 概要 壱万円日本銀行券(「壱」が大字) 弐千円日本銀行券(「弐」が大字) 漢数字には「一」「二」「三」と続く小字と、「壱」「弐」…

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